经口内镜下鼻窦底提升术用于兔模型中生物材料研究。
Sinus Floor Augmentation by Intraoral Endoscopic Approach for Biomaterial Study in a Rabbit Model.
机构信息
Biomedical Department, Universidad de Antofagasta, Antofagasta, Chile.
Dental School, Clinical Investigation and Dental Innovation Center (CIDIC), Universidad de La Frontera, Temuco, Chile
出版信息
In Vivo. 2019 Nov-Dec;33(6):1843-1849. doi: 10.21873/invivo.11677.
AIM
To develop a new surgical model for sinus floor augmentation (SFA) in rabbit for experimental purposes.
MATERIALS AND METHODS
Eight adult rabbits were used, two for a surgical design using the anatomical dissection study, and the other six for an endoscopically assisted intraoral approach of SFA unilaterally, creating a subantral space where an allograft biomaterial was deposited. SFA was verified through cone-beam computerized tomography. Healing, weight, food, feces, and behavior were evaluated for 4 weeks post-operatively.
RESULTS
All animals survived. There was no bleeding or infection; inflammation was mild. No changes were observed in terms of feeding, weight, feces, or behavior. Tissue healing was normal.
CONCLUSION
This model is a refinement of the experimental technique and is a real option for SFA, without compromising animal morbidity because of its conservative design. The minimally invasive approach with endoscopic assistance reduces bias and improves surgical predictability.
目的
为实验目的开发一种新的兔鼻窦提升（SFA）手术模型。
材料和方法
使用了 8 只成年兔，其中 2 只为解剖研究的手术设计，另外 6 只为单侧经口内镜辅助 SFA ，在其中创建一个亚窦腔，在此处沉积同种异体生物材料。通过锥形束计算机断层扫描验证 SFA。术后 4 周评估愈合、体重、饮食、粪便和行为。
结果
所有动物均存活。无出血或感染；炎症较轻。饮食、体重、粪便或行为均无变化。组织愈合正常。
结论
该模型是实验技术的改进，是 SFA 的一个可行选择，不会因设计保守而增加动物发病率。经内镜辅助的微创方法减少了偏差，提高了手术的可预测性。
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