腮腺鳞状细胞癌的异质性：49 例患者研究。
The Heterogenicity of Parotid Gland Squamous Cell Carcinoma: A Study of 49 Patients.
机构信息
Department of Otorhinolaryngology, Head and Neck Surgery, Brandenburg Medical University-Theodor Fontane, Campus Ruppiner Kliniken, Neuruppin, Germany
Department of Otorhinolaryngology, Head and Neck Surgery, Brandenburg Medical University-Theodor Fontane, Campus Ruppiner Kliniken, Neuruppin, Germany.
出版信息
In Vivo. 2019 Nov-Dec;33(6):2001-2006. doi: 10.21873/invivo.11696.
BACKGROUND/AIM: The aim of this study was to critically evaluate diagnostic workup, treatment and outcome of parotid gland squamous cell carcinoma (SCC).
PATIENTS AND METHODS
We retrospectively examined 844 consecutive cases of parotid surgery in a German teaching hospital between 1975 and 2017.
RESULTS
A total of 748 patients had parotid surgery. A total of 118 patients (15.7%) had a malignant tumour. Of those 49 patients had SCC accounting for 6.6% of all cases, and 41.5% of all malignant tumours. SCC typically affected males (79.6%) of advanced age. A total of 86% of patients had metastatic disease; three cases were primary SCC. Most primary carcinomas were skin (n=26) or pharynx (n=10). Four cases were carcinomas of unknown primary. We performed radical parotidectomy in 47 cases, neck dissections in 42 cases and adjuvant chemo-radiotherapy in 44 cases.
CONCLUSION
The majority of parotid SCC are metastases. In cases without known primary lesion and lack of infiltrative tumour growth, a carcinoma with unknown primary should be considered.
背景/目的：本研究旨在批判性地评估腮腺鳞状细胞癌（SCC）的诊断检查、治疗和预后。
患者和方法
我们回顾性检查了 1975 年至 2017 年期间在一家德国教学医院接受腮腺手术的 844 例连续病例。
结果
共有 748 例患者接受了腮腺手术。共有 118 例（15.7%）患者患有恶性肿瘤。其中 49 例为 SCC，占所有病例的 6.6%，占所有恶性肿瘤的 41.5%。SCC 通常影响男性（79.6%）和老年患者。共有 86%的患者发生了转移性疾病；3 例为原发性 SCC。大多数原发性癌是皮肤（n=26）或咽部（n=10）。4 例为不明原发灶的癌。我们对 47 例患者进行了根治性腮腺切除术，对 42 例患者进行了颈部清扫术，对 44 例患者进行了辅助放化疗。
结论
大多数腮腺 SCC 是转移瘤。在没有已知原发病灶且无浸润性肿瘤生长的情况下，应考虑不明原发灶的癌。
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