比较烧结和未烧结异种骨替代物的材料介导骨再生能力的 2D 和 3D 数据。
Comparison of Material-mediated Bone Regeneration Capacities of Sintered and Non-sintered Xenogeneic Bone Substitutes 2D and 3D Data.
机构信息
Department of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany.
Department of Oral and Maxillofacial Surgery, University Hospital Hamburg-Eppendorf, Hamburg, Germany
出版信息
In Vivo. 2019 Nov-Dec;33(6):2169-2179. doi: 10.21873/invivo.11719.
Abstract
BACKGROUND/AIM: The aim of this study was the development of a new osteoconductivity index to determine the bone healing capacities of bone substitute materials (BSM) on the basis of 3D microcomputed tomographic (μ-CT) data.
MATERIALS AND METHODS
Sinus biopsies were used for the comparative analysis of the integration behavior of two xenogeneic BSM (cerabone® and Bio-Oss®). 3D μ-CT and data sets from histomorphometrical measurements based on 2D histological slices were used to measure the bone-material-contact and the tissue distribution within the biopsies. The tissue reactions to both BSM were microscopically analyzed.
RESULTS
The 3D and 2D results of the osteoconductivity measurements showed comparable material-bone contacts for both BSM, but the 2D data were significantly lower. The same results were found when tissue distribution was measured in both groups. The histopathological analysis showed comparative tissue reactions in both BSM.
CONCLUSION
Osteoconductivity index is a reliable measurement parameter for determining the healing capacities of BSM. The observed differences between both measurement methods could be assigned to the resolution capacity of μ-CT data that did not allow for a precise interface distinction between both BSM and bone tissue. Histomorphometrical data based on histological slides still allow for a more exact evaluation.
摘要
背景/目的：本研究旨在开发一种新的骨传导性指数，以基于 3D 微计算机断层扫描（μ-CT）数据来确定骨替代材料（BSM）的骨愈合能力。
材料和方法
使用鼻窦活检来比较分析两种异种 BSM（cerabone®和 Bio-Oss®）的整合行为。使用 3D μ-CT 和基于 2D 组织学切片的组织计量学测量数据集来测量活检内的骨-材料接触和组织分布。对两种 BSM 的组织反应进行了显微镜分析。
结果
骨传导性测量的 3D 和 2D 结果显示两种 BSM 的材料-骨接触相似，但 2D 数据明显较低。在两组中测量组织分布时也发现了相同的结果。组织病理学分析显示两种 BSM 的组织反应相似。
结论
骨传导性指数是确定 BSM 愈合能力的可靠测量参数。两种测量方法之间观察到的差异可归因于 μ-CT 数据的分辨率能力，这使得无法在两种 BSM 和骨组织之间进行精确的界面区分。基于组织学切片的组织计量学数据仍然允许更精确的评估。
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