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由碳酸磷灰石组成的颗粒状蜂窝支架，用于同时进行颗粒内和颗粒间的成骨作用和血管生成。

Granular honeycomb scaffolds composed of carbonate apatite for simultaneous intra- and inter-granular osteogenesis and angiogenesis.

作者信息

Hayashi Koichiro, Yanagisawa Toshiki, Shimabukuro Masaya, Kishida Ryo, Ishikawa Kunio

机构信息

Department of Biomaterials, Faculty of Dental Science, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan.

出版信息

Mater Today Bio. 2022 Mar 26;14:100247. doi: 10.1016/j.mtbio.2022.100247. eCollection 2022 Mar.

DOI:10.1016/j.mtbio.2022.100247
PMID:35378911
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC8976130/
Abstract

Granular porous calcium phosphate scaffolds are used for bone regeneration in dentistry. However, in conventional granules, the macropore interconnectivity is poor and has varying size. Herein, we developed a productive method for fabricating carbonate apatite honeycomb granules with uniformly sized macropores based on extrusion molding. Each honeycomb granule possesses three hexagonal macropores of ∼290 ​μm along its diagonal. Owing to these macropores, honeycomb granules simultaneously formed new and mature bone and blood vessels in both the interior and exterior of the granules at 4 weeks after implantation. The honeycomb granules are useful for achieving rapid osteogenesis and angiogenesis.

摘要

粒状多孔磷酸钙支架用于牙科的骨再生。然而，在传统颗粒中，大孔的相互连通性较差且尺寸各异。在此，我们基于挤出成型开发了一种生产方法，用于制造具有均匀尺寸大孔的碳酸磷灰石蜂窝状颗粒。每个蜂窝状颗粒沿其对角线具有三个约290μm的六边形大孔。由于这些大孔，蜂窝状颗粒在植入后4周时，在颗粒的内部和外部同时形成了新的成熟骨和血管。蜂窝状颗粒有助于实现快速成骨和血管生成。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/9634445e6d1e/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/d5b11fef9a0b/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/1f4db4f061cb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/cdd5b79a454e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/e4738e85a59c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/314be2cea41d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/42d8ee50df38/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/97393849260e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/4af07bc729d3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/c847d1091898/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/206a8d2a0190/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/9634445e6d1e/gr10.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/d5b11fef9a0b/ga1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/1f4db4f061cb/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/cdd5b79a454e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/e4738e85a59c/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/314be2cea41d/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/42d8ee50df38/gr5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/97393849260e/gr6.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/4af07bc729d3/gr7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/c847d1091898/gr8.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/206a8d2a0190/gr9.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/de0b/8976130/9634445e6d1e/gr10.jpg

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