Department of Orthopedic Surgery, Graduate School of Medical Science, Nagoya City University, Nagoya, Japan.
Department of Orthopedic Surgery, Graduate School of Medical Science, Kanazawa University, Kanazawa, Japan.
In Vivo. 2019 Nov-Dec;33(6):2235-2240. doi: 10.21873/invivo.11728.
BACKGROUND/AIM: Although some patients with enchondroma have multiple lesions, no study has investigated the distribution of lesions in patients with multiple enchondromas.
This retrospective study included 118 patients with enchondroma of the hand. The incidence and characteristic feature of multiple enchondromas of the hand were investigated.
Four patients (3.4%) had multiple enchondromas. In all the patients with multiple enchondromas, the lesions occurred in the middle phalanx, proximal phalanx, and metacarpal bone in the same digital ray.
The development of the hand rapidly progresses from intrauterine day 33 to day 54. The digital rays are evident on intrauterine day 41, and separation of the distal phalanx, middle phalanx, proximal phalanx, and metacarpal bone is completed until intrauterine day 54. The successive occurrence of multiple enchondroma lesions in the same digital ray in all four cases suggests that the occurrence of lesions preceded the separation of the hand bones and the lesions were divided during the development of these bones.
背景/目的：尽管有些内生软骨瘤患者有多发性病变，但尚无研究调查多发性内生软骨瘤患者的病变分布。
本回顾性研究纳入了 118 例手部内生软骨瘤患者。调查了手部多发性内生软骨瘤的发生率和特征。
4 例（3.4%）患者有多发性内生软骨瘤。在所有多发性内生软骨瘤患者中，病变均发生在同一手指的中节指骨、近节指骨和掌骨。
手的发育从宫内第 33 天到第 54 天迅速进展。宫内第 41 天可见指骨，直到宫内第 54 天，远节指骨、中节指骨、近节指骨和掌骨才完全分离。所有 4 例患者同一手指上的多发性内生软骨瘤病变相继发生，这提示病变发生在手骨分离之前，病变是在这些骨发育过程中发生的。
