Neurology/Neurosurgery Service, Animal Health Trust, Newmarket, UK
Neurology/Neurosurgery Service, Animal Health Trust, Newmarket, UK.
Vet Rec. 2020 May 30;186(17):e13. doi: 10.1136/vr.105636. Epub 2019 Oct 29.
The English setter (ES) is predisposed to congenital sensorineural deafness (CSD). CSD prevalence and association with phenotype in the UK ES population are previously unreported.
The database of the authors' institution was searched for ES puppies undergoing brainstem auditory evoked response (BAER) testing for CSD screening (2000-2018). Inclusion criteria were BAER performed at 5-10 weeks of age, testing of complete litters and available phenotypic data. The age, sex, presence of patches at birth, coat colour, iris colour, hearing status and BAER-determined parental hearing status of each puppy were recorded. Multivariable binary logistic regression was performed to determine the significance of these variables as predictors for the likelihood of puppies being unilaterally or bilaterally deaf.
Inclusion criteria were met for 447 puppies. Hearing was bilaterally normal in 427 (95.5 per cent) puppies. The prevalence of unilateral and bilateral CSD was 3.6 per cent and 0.9 per cent, respectively. Females were 3.3 times more likely to be deaf than males, and puppies with both parents of unknown hearing status were 4.6 times more likely to be deaf than those with at least one normal parent.
The prevalence of CSD was 4.5 per cent, with female puppies and those with two parents of unknown hearing status at greatest risk.
英国塞特犬（ES）易患先天性感觉神经性耳聋（CSD）。英国 ES 犬群中 CSD 的流行情况及其与表型的关系此前尚未报道。
作者所在机构的数据库中搜索了在 5-10 周龄时进行脑干听觉诱发电位（BAER）测试以进行 CSD 筛查的 ES 幼犬（2000-2018 年）。纳入标准为在 5-10 周龄时进行 BAER 测试，对完整窝进行测试，并且具有可用的表型数据。记录每只幼犬的年龄、性别、出生时是否有斑块、被毛颜色、虹膜颜色、听力状况以及 BAER 确定的父母听力状况。采用多变量二项逻辑回归来确定这些变量作为预测单侧或双侧耳聋可能性的指标的意义。
符合纳入标准的幼犬有 447 只。427 只（95.5%）幼犬的听力双侧正常。单侧和双侧 CSD 的患病率分别为 3.6%和 0.9%。雌性耳聋的可能性是雄性的 3.3 倍，双亲听力状况未知的幼犬耳聋的可能性是双亲至少有一方听力正常的幼犬的 4.6 倍。
CSD 的患病率为 4.5%，雌性幼犬和双亲听力状况未知的幼犬风险最大。
