Lagunas-Cruz María Del Carmen, Valle-Mendiola Arturo, Trejo-Huerta Jonathan, Rocha-Zavaleta Leticia, Mora-García María de Lourdes, Gutiérrez-Hoya Adriana, Weiss-Steider Benny, Soto-Cruz Isabel
Molecular Oncology Laboratory, Cell Differentiation and Cancer Research Unit, FES Zaragoza, National University of Mexico, Batalla 5 de Mayo S/n Col. Ejército de Oriente, CP 09230 Mexico City, Mexico.
Department of Molecular Biology and Biotechnology, Institute of Biomedical Research, National University of Mexico, Mexico City, Mexico.
J Oncol. 2019 Sep 26;2019:7475295. doi: 10.1155/2019/7475295. eCollection 2019.
Interleukin 2 (IL-2) has been used for the treatment of different types of cancer that express the IL-2 receptor (IL-2R). However, the effect of IL-2 on cervical cancer cells is unknown. IL-2R is present in normal cells of the immune system but not in the healthy cervix. We report that IL-2R is expressed in cervical cancer cells. IL-2 decreases cervical cancer cell proliferation via transient arrest of the G1 phase, which does not result in apoptosis or senescence. IL-2 upregulates the expression of p53 and p21 and downregulates cyclin D. In addition, we report the resistance of cervical cancer cells to treatments that induce apoptosis in HeLa and INBL cells. When arrested cells were treated with cisplatin, the cytokine protected cells from apoptosis induced by cisplatin. The effects of IL-2 on the cell cycle do not induce cellular senescence or activate the proapoptotic protein Bax. The cell arrest induced by IL-2 is conferring protection to cells against apoptosis.
白细胞介素2（IL-2）已被用于治疗表达白细胞介素2受体（IL-2R）的不同类型癌症。然而，IL-2对宫颈癌细胞的作用尚不清楚。IL-2R存在于免疫系统的正常细胞中，但不存在于健康的子宫颈中。我们报告IL-2R在宫颈癌细胞中表达。IL-2通过短暂阻滞G1期来降低宫颈癌细胞增殖，这不会导致细胞凋亡或衰老。IL-2上调p53和p21的表达并下调细胞周期蛋白D。此外，我们报告了宫颈癌细胞对诱导HeLa和INBL细胞凋亡的治疗具有抗性。当用顺铂处理停滞的细胞时，该细胞因子可保护细胞免受顺铂诱导的凋亡。IL-2对细胞周期的影响不会诱导细胞衰老或激活促凋亡蛋白Bax。IL-2诱导的细胞停滞为细胞提供了抗凋亡保护。
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