Ozarslan Nida, Robinson Joshua F, Gaw Stephanie L
Marmara University School of Medicine, Istanbul, Turkey.
Center for Reproductive Sciences, Department of Obstetrics, Gynecology & Reproductive Sciences, University of California, San Francisco, CA, USA.
J Trop Med. 2019 Oct 2;2019:3720838. doi: 10.1155/2019/3720838. eCollection 2019.
Malaria is a significant cause of global morbidity and mortality. The parasite has a complex life cycle with mosquito, liver, and blood stages. The blood stages can preferentially affect organs such as the brain and placenta. In each of these stages and organs, the parasite will encounter monocytes and tissue-specific macrophages-key cell types in the innate immune response. Interactions between the parasite and monocytes/macrophages lead to several changes at both cellular and molecular levels, such as cytokine release and receptor expression. In this review, we summarize current knowledge on the relationship between malaria and blood intervillous monocytes and tissue-specific macrophages of the liver (Kupffer cells), central nervous system (microglia), and placenta (maternal intervillous monocytes and fetal Hofbauer cells). We describe their potential roles in modulating outcomes from infection and areas for future investigation.
疟疾是全球发病和死亡的一个重要原因。疟原虫具有复杂的生命周期，包括蚊子、肝脏和血液阶段。血液阶段可优先影响大脑和胎盘等器官。在这些阶段和器官中的每一个，疟原虫都会遇到单核细胞和组织特异性巨噬细胞——先天免疫反应中的关键细胞类型。疟原虫与单核细胞/巨噬细胞之间的相互作用会在细胞和分子水平上导致多种变化，如细胞因子释放和受体表达。在本综述中，我们总结了关于疟疾与肝（库普弗细胞）、中枢神经系统（小胶质细胞）和胎盘（母体绒毛间隙单核细胞和胎儿霍夫鲍尔细胞）的血液绒毛间隙单核细胞及组织特异性巨噬细胞之间关系的现有知识。我们描述了它们在调节感染结果中的潜在作用以及未来的研究方向。
