Department of Industrial Engineering, Fraunhofer JL IDEAS-University of Naples Federico II, P.le Tecchio 80, 80125 Naples, Italy.
Institute of Polymers, Composites and Biomaterials-National Research Council of Italy, V.le J.F. Kennedy 54-Mostra d'Oltremare Pad. 20, 80125 Naples, Italy.
J Healthc Eng. 2019 Sep 22;2019:3212594. doi: 10.1155/2019/3212594. eCollection 2019.
Mechanical and architectural features play an important role in designing biomedical devices. The use of materials (i.e., Ti6Al4V) with Young's modulus higher than those of natural tissues generally cause stress shielding effects, bone atrophy, and implant loosening. However, porous devices may be designed to reduce the implant stiffness and, consequently, to improve its stability by promoting tissue ingrowth. If porosity increases, mass transport properties, which are crucial for cell behavior and tissue ingrowth, increase, whereas mechanical properties decrease. As reported in the literature, it is always possible to tailor mass transport and mechanical properties of additively manufactured structures by varying the architectural features, as well as pore shape and size. Even though many studies have already been made on different porous structures with controlled morphology, the aim of current study was to provide only a further analysis on Ti6Al4V lattice structures manufactured by selective laser melting. Experimental and theoretical analyses also demonstrated the possibility to vary the architectural features, pore size, and geometry, without dramatically altering the mechanical performance of the structure.
机械和建筑特性在设计生物医学设备中起着重要作用。使用杨氏模量高于天然组织的材料（例如 Ti6Al4V）通常会导致应力屏蔽效应、骨萎缩和植入物松动。然而，可以设计多孔设备来降低植入物的刚度，从而通过促进组织长入来提高其稳定性。如果孔隙率增加，则对于细胞行为和组织长入至关重要的传质特性会增加，而机械性能会降低。正如文献中所报道的，通过改变建筑特性以及孔的形状和大小，总是可以调整增材制造结构的传质和机械性能。尽管已经有许多关于具有受控形态的不同多孔结构的研究，但当前研究的目的仅是对通过选择性激光熔化制造的 Ti6Al4V 晶格结构进行进一步分析。实验和理论分析还证明了在不显著改变结构机械性能的情况下改变建筑特性、孔径和几何形状的可能性。
