Department of Spinal Surgery, Drum Tower Hospital, Medical School of Nanjing University, Nanjing, China.
Orthop Surg. 2009 Feb;1(1):78-83. doi: 10.1111/j.1757-7861.2008.00014.x.
To investigate the microstructure of trabecular bone in adolescent idiopathic scoliosis (AIS) and age-matched congenital scoliosis (CS), and to evaluate the bone mineral status of CS patients compared with normal controls and AIS patients.
This study included 15 AIS and 16 CS female patients and 35 healthy female adolescents. Corrective surgery was indicated for the AIS and CS patients, from whom iliac crest biopsies were collected during autograft harvesting, and scanned by micro-computer tomography. Bone mineral status was assessed at the lumbar and hip areas in every patient by dual energy X-ray absorptiometry (DEXA).
Significantly lower lumbar and femoral neck bone mineral density (BMD) was found in AIS patient compared with normal controls. All BMD and bone mineral content (BMC) parameters were significantly lower in CS patients compared with age-matched normal controls. Under DEXA assessment significant associations between bone volume/tissue volume (BV/TV) and BMD values were observed. In the 3D model, BV/TV was significantly higher in AIS (19.9% ± 3.4%) than in CS (13.3% ± 3.0%, P < 0.05). Significant differences between AIS and CS were also found in trabecular thickness (Tb.Th) and bone surface/bone volume (BS/BV) (155.5 ± 54.9 µm vs. 108.1 ± 17.4 µm and 16.4% ± 3.3% vs. 22.0% ± 3.4% respectively, P < 0.05 in both).
Lower bone mineral status and weak trabecular bone structure observed in AIS and CS justify further investigation of the bone mineral status in scoliosis of various etiologies.
研究青少年特发性脊柱侧凸（AIS）和年龄匹配的先天性脊柱侧凸（CS）的小梁骨微观结构，并评估 CS 患者与正常对照和 AIS 患者的骨矿物质状态。
本研究纳入 15 例 AIS 和 16 例 CS 女性患者和 35 名健康的女性青少年。AIS 和 CS 患者因矫形手术需要，从自体骨采集时取髂嵴活检，通过微计算机断层扫描进行扫描。每位患者均通过双能 X 射线吸收法（DEXA）评估腰椎和髋部的骨矿物质状态。
与正常对照组相比，AIS 患者的腰椎和股骨颈骨矿物质密度（BMD）显著降低。CS 患者的所有 BMD 和骨矿物质含量（BMC）参数均明显低于年龄匹配的正常对照组。DEXA 评估显示骨体积/组织体积（BV/TV）与 BMD 值之间存在显著相关性。在 3D 模型中，AIS（19.9%±3.4%）患者的 BV/TV 显著高于 CS（13.3%±3.0%，P<0.05）。AIS 和 CS 患者的骨小梁厚度（Tb.Th）和骨表面/骨体积（BS/BV）也存在显著差异（分别为 155.5±54.9μm 比 108.1±17.4μm 和 16.4%±3.3%比 22.0%±3.4%，均 P<0.05）。
在 AIS 和 CS 中观察到的骨矿物质状态较低和小梁骨结构较弱，证明有必要进一步研究各种病因的脊柱侧凸的骨矿物质状态。
