Department of Environmental Hygiene, Public Health College, Harbin Medical University, Harbin, China.
Harbin Center for Disease Control and Prevention, Harbin, China.
Biomed Res Int. 2019 Sep 24;2019:2457964. doi: 10.1155/2019/2457964. eCollection 2019.
Given the lack of research on the schoolchildren exposure to PM2.5-bound PHAs in northeast China, we investigated the effects of exposure to ambient benzo[b]fluoranthene (BbFA) and dibenz[a,h]anthracene (DahA) bound to PM2.5 on pulmonary ventilation dysfunction (PVD) and small airway dysfunction (SAD). PM2.5 samples at two schools (A and B) were collected, and the concentrations of PM2.5-bound 4-6-ring PAHs were analyzed. PVD and SAD were evaluated by pulmonary function tests in 306 students while urinary MDA and CRP levels were measured. The results confirmed that ambient PM2.5-bound 4-6-ring PHA levels were significantly higher and the PVD and SAD incidence in schools A and B were increased during the heating season. We found that PM2.5-bound BbFA, BkFA, BaP, and DahA levels were only correlated with SAD in schoolchildren; the correlation coefficients of BbFA and DahA were the highest effect estimates, possibly due to altered MDA levels. Therefore, this research enables us to better understand the effects of exposure to ambient PM2.5-bound PHAs on pulmonary function parameters. Our results also showed that identification of hazardous PM2.5-bound BbFA and DahA to health is crucial for preventing the respiratory-related diseases.
鉴于东北地区在校儿童对 PM2.5 结合态多环芳烃暴露的研究较少，我们调查了暴露于大气苯并[b]荧蒽（BbFA）和二苯并[a,h]蒽（DahA）与 PM2.5 结合对肺通气功能障碍（PVD）和小气道功能障碍（SAD）的影响。在两所学校（A 和 B）采集 PM2.5 样本，并分析 PM2.5 结合态 4-6 环多环芳烃的浓度。在 306 名学生中通过肺功能测试评估 PVD 和 SAD，并测量尿丙二醛（MDA）和 C 反应蛋白（CRP）水平。结果证实，大气 PM2.5 结合态 4-6 环 PHA 水平显著升高，且在供暖季 A、B 两校 PVD 和 SAD 发病率升高。我们发现，PM2.5 结合态 BbFA、BkFA、BaP 和 DahA 水平仅与在校儿童 SAD 相关；BbFA 和 DahA 的相关系数为最高的效应估计值，可能是由于 MDA 水平改变。因此，本研究使我们能够更好地了解暴露于大气 PM2.5 结合态多环芳烃对肺功能参数的影响。我们的研究结果还表明，确定对健康有危害的 PM2.5 结合态 BbFA 和 DahA 对于预防与呼吸相关的疾病至关重要。
