利用噬菌体策略调控细菌转录。
Exploiting phage strategies to modulate bacterial transcription.
作者信息
Wahl Markus C, Sen Ranjan
机构信息
Freie Universität Berlin, Laboratory of Structural Biochemistry, Berlin, Germany.
Helmholtz-Zentrum Berlin für Materialien und Energie, Macromolecular Crystallography, Berlin, Germany.
出版信息
Transcription. 2019 Aug-Oct;10(4-5):222-230. doi: 10.1080/21541264.2019.1684137. Epub 2019 Oct 30.
Abstract
Bacteriophages employ small proteins to usurp host molecular machinery, thereby interfering with central metabolic processes in infected bacteria. Generally, phages inhibit or redirect host transcription to favor transcription of their own genomes. Mechanistic and structural studies of phage-modulated host transcription may provide inspirations for the development of novel antibacterial substances.
摘要
噬菌体利用小蛋白夺取宿主分子机制，从而干扰受感染细菌的中心代谢过程。一般来说，噬菌体抑制或重定向宿主转录，以利于其自身基因组的转录。对噬菌体调节宿主转录的机制和结构研究可能为新型抗菌物质的开发提供灵感。
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本文引用的文献
1
Structural basis of Q-dependent antitermination.
Proc Natl Acad Sci U S A. 2019 Sep 10;116(37):18384-18390. doi: 10.1073/pnas.1909801116. Epub 2019 Aug 27.
2
Structural basis of σ appropriation.
Nucleic Acids Res. 2019 Sep 26;47(17):9423-9432. doi: 10.1093/nar/gkz682.
3
Structural basis for transcription antitermination at bacterial intrinsic terminator.
Nat Commun. 2019 Jul 11;10(1):3048. doi: 10.1038/s41467-019-10955-x.
4
Structural basis of Q-dependent transcription antitermination.
Nat Commun. 2019 Jul 2;10(1):2925. doi: 10.1038/s41467-019-10958-8.
5
Antimicrobial Peptides: An Approach to Combat Resilient Infections.
Curr Drug Discov Technol. 2020;17(4):542-552. doi: 10.2174/1570163816666190620114338.
6
Where to begin? Sigma factors and the selectivity of transcription initiation in bacteria.
Mol Microbiol. 2019 Aug;112(2):335-347. doi: 10.1111/mmi.14309. Epub 2019 Jun 3.
7
A mycobacteriophage genomics approach to identify novel mycobacteriophage proteins with mycobactericidal properties.
Microbiology (Reading). 2019 Jul;165(7):722-736. doi: 10.1099/mic.0.000810. Epub 2019 May 15.
8
Structural Basis for the Action of an All-Purpose Transcription Anti-termination Factor.
Mol Cell. 2019 Apr 4;74(1):143-157.e5. doi: 10.1016/j.molcel.2019.01.016. Epub 2019 Feb 19.
9
Xenogeneic Regulation of the Bacterial Transcription Machinery.
J Mol Biol. 2019 Sep 20;431(20):4078-4092. doi: 10.1016/j.jmb.2019.02.008. Epub 2019 Feb 15.
10
Processive Antitermination.
Microbiol Spectr. 2018 Sep;6(5). doi: 10.1128/microbiolspec.RWR-0031-2018.
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