利用噬菌体策略调控细菌转录。
Exploiting phage strategies to modulate bacterial transcription.
作者信息
Wahl Markus C, Sen Ranjan
机构信息
Freie Universität Berlin, Laboratory of Structural Biochemistry, Berlin, Germany.
Helmholtz-Zentrum Berlin für Materialien und Energie, Macromolecular Crystallography, Berlin, Germany.
出版信息
Transcription. 2019 Aug-Oct;10(4-5):222-230. doi: 10.1080/21541264.2019.1684137. Epub 2019 Oct 30.
Abstract
Bacteriophages employ small proteins to usurp host molecular machinery, thereby interfering with central metabolic processes in infected bacteria. Generally, phages inhibit or redirect host transcription to favor transcription of their own genomes. Mechanistic and structural studies of phage-modulated host transcription may provide inspirations for the development of novel antibacterial substances.
摘要
噬菌体利用小蛋白夺取宿主分子机制，从而干扰受感染细菌的中心代谢过程。一般来说，噬菌体抑制或重定向宿主转录，以利于其自身基因组的转录。对噬菌体调节宿主转录的机制和结构研究可能为新型抗菌物质的开发提供灵感。
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