Department of Ophthalmology (H.S., J.-W.K.), Myongji Hospital, Hanyang University College of Medicine, Goyang, Korea; and Department of Ophthalmology and Visual Sciences (G.M.R.), Montefiore Medical Center, Bronx, NY.
Eye Contact Lens. 2019 Nov;45(6):394-398. doi: 10.1097/ICL.0000000000000574.
To investigate clinical features and treatment outcomes of pingueculitis with morphological assessments using anterior segment optical coherence tomography (AS-OCT).
In this retrospective observational study, we examined 22 eyes of 22 patients with pingueculitis. All patients were treated with the same 2-week course of prednisolone acetate 1% drops four times per day. The clinical parameters evaluated were surface dimensions determined by slitlamp biomicroscopy, cross-sectional dimensions determined by AS-OCT, and symptom scores determined by patient surveys. Pretreatment and 1-month posttreatment values were compared with Wilcoxon signed-rank tests. Patients were followed up to 1 year after treatment.
Twenty-two eyes from 22 patients (4 men and 18 women) with an average age of 37.7±8.8 (range, 27-57) years and an average duration of symptoms of 22 (range, 5-60) days were included. The average follow-up period was 14.7±0.8 (range, 12-22) months. Mean pretreatment horizontal length, vertical length, conjunctival thickness, and cross-sectional area were 2.4±0.69 mm, 2.0±0.6 mm, 1.82±0.60 μm, and 5.14±2.05 mm, respectively. Mean posttreatment horizontal length, vertical length, conjunctival thickness, and area were 1.93±0.5 mm, 1.52±0.6 mm, 1.03±0.46 μm, and 2.33±0.83 mm, respectively. Mean pretreatment and posttreatment dry eye symptom scores were 3.27±0.77 and 1.13±0.38, respectively. The median pretreatment and posttreatment changes were statistically significant by Wilcoxon signed-rank tests for horizontal length (P<0.001), vertical length (P<0.001), conjunctival thickness (P=0.003), cross-sectional area (P=0.003), and dry eye symptom scores (P<0.001).
Anterior segment optical coherence tomography allows the quantification of differences in the pingueculitis measurements before and after treatment. In this retrospective study, a short course of topical steroids effectively treated the inflammation in a sustained manner. Anterior segment optical coherence tomography demonstrated significant reduction in the thickness and cross-sectional area of the pinguecula and a conversion back to a homogeneous conjunctival stroma.
使用眼前节光学相干断层扫描（AS-OCT）对睑裂斑炎进行形态学评估，探讨其临床特征和治疗效果。
本回顾性观察研究纳入了 22 例（22 只眼）睑裂斑炎患者。所有患者均接受为期 2 周的醋酸泼尼松龙 1%滴眼治疗，每日 4 次。评估的临床参数包括裂隙灯生物显微镜测量的表面尺寸、AS-OCT 测量的横截面尺寸和患者调查的症状评分。采用 Wilcoxon 符号秩检验比较治疗前和治疗后 1 个月的数值。患者接受治疗后随访 1 年。
本研究纳入了 22 例（4 名男性和 18 名女性）患者的 22 只眼，平均年龄为 37.7±8.8（范围：27-57）岁，平均症状持续时间为 22（范围：5-60）天。平均随访时间为 14.7±0.8（范围：12-22）个月。治疗前，水平长度、垂直长度、结膜厚度和横截面积的平均值分别为 2.4±0.69mm、2.0±0.6mm、1.82±0.60μm 和 5.14±2.05mm。治疗后，水平长度、垂直长度、结膜厚度和面积的平均值分别为 1.93±0.5mm、1.52±0.6mm、1.03±0.46μm 和 2.33±0.83mm。治疗前和治疗后干眼症症状评分的平均值分别为 3.27±0.77 和 1.13±0.38。Wilcoxon 符号秩检验显示，水平长度（P<0.001）、垂直长度（P<0.001）、结膜厚度（P=0.003）、横截面积（P=0.003）和干眼症症状评分（P<0.001）的治疗前后中位数变化均具有统计学意义。
眼前节光学相干断层扫描可定量评估治疗前后睑裂斑炎的变化。在这项回顾性研究中，短期局部皮质类固醇治疗可持续有效治疗炎症。眼前节光学相干断层扫描显示，睑裂斑的厚度和横截面积显著减少，结膜基质恢复为均匀一致的外观。
