Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; The Key Laboratory of Major Autoimmune Diseases, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China.
Department of Epidemiology and Biostatistics, School of Public Health, Anhui Medical University, 81 Meishan Road, Hefei, Anhui 230032, China; Department of Rheumatism and Immunity, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui 230022, China.
Clin Immunol. 2020 Apr;213:108374. doi: 10.1016/j.clim.2020.108374. Epub 2020 Mar 5.
The association between Interleukin (IL)-17A and IL-17F gene polymorphism with inflammatory arthritis were inconsistent among previous studies. This meta-analysis aimed to determine the association between IL-17A and IL-17F gene polymorphism with ankylosing spondylitis (AS), osteoarthritis (OA) and rheumatoid arthritis (RA).
We searched Medline up to August 2019. The summary Odds Ratio (OR) with corresponding 95% confidence intervals (CIs) was calculated to evaluate the relationship between IL-17A and IL-17F gene polymorphism with genetic susceptibility of AS, OA and RA.
A total of 19 studies with 5298 cases and 5675 healthy controls were included. There were significant associations between rs2275913 G allele with OA, RA susceptibility (P < .05) but not AS. Subgroup analysis by ethnicity indicated that rs763780 C allele was closely related to AS and OA in Caucasian populations (P < .001) but not Mongolians. A significant association between rs763780 and RA susceptibility was detected in Caucasian populations (P < .05).
IL-17F gene rs763780 C allele confers increased risk of inflammatory arthritis in Caucasians; IL-17A gene rs2275913 G allele are protective for OA susceptibility in Mongolians. More well-designed studies with larger sample size are needed to elucidate the role of IL-17A gene rs2275913 G allele in inflammatory arthritis, especially AS.
白细胞介素（IL）-17A 和 IL-17F 基因多态性与炎症性关节炎的相关性在先前的研究中并不一致。本荟萃分析旨在确定 IL-17A 和 IL-17F 基因多态性与强直性脊柱炎（AS）、骨关节炎（OA）和类风湿关节炎（RA）之间的关系。
我们检索了截至 2019 年 8 月的 Medline。计算汇总优势比（OR）及其相应的 95%置信区间（CI），以评估 IL-17A 和 IL-17F 基因多态性与 AS、OA 和 RA 遗传易感性的关系。
共纳入 19 项研究，包括 5298 例病例和 5675 例健康对照。rs2275913 G 等位基因与 OA、RA 易感性相关（P<0.05），但与 AS 无关。按种族进行的亚组分析表明，rs763780 C 等位基因与白种人群的 AS 和 OA 密切相关（P<0.001），但与蒙古人群无关。在白种人群中，rs763780 与 RA 易感性显著相关（P<0.05）。
IL-17F 基因 rs763780 C 等位基因增加了白种人群炎症性关节炎的风险；IL-17A 基因 rs2275913 G 等位基因对蒙古人群的 OA 易感性具有保护作用。需要更多设计良好、样本量更大的研究来阐明 IL-17A 基因 rs2275913 G 等位基因在炎症性关节炎，特别是 AS 中的作用。
