Cardiovascular Disease Research Center, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Haidian District, Beijing, 100091, China.
Heart Fail Rev. 2020 Nov;25(6):1037-1045. doi: 10.1007/s10741-019-09882-2.
Cardiac hypertrophy (CH) is generally considered adaptive responses that may occur after myocardial infarction, pressure overload, volume overload, inflammatory heart muscle disease, or idiopathic dilated cardiomyopathy, whereas long-term stimulation eventually leads to heart failure (HF). However, the current molecular mechanisms involved in CH are unclear. Recently, increasing evidences reveal that long non-coding RNAs (lncRNAs) play vital roles in CH. Different lncRNAs can promote or inhibit the pathological process of CH by different mechanisms, while the regulation of lncRNAs expression can improve CH. Thus, CH-related lncRNAs may become a novel field of research on CH.
心肌肥厚（CH）通常被认为是心肌梗死后、压力超负荷、容量超负荷、炎症性心肌病或特发性扩张型心肌病等情况下可能发生的适应性反应，而长期刺激最终会导致心力衰竭（HF）。然而，目前涉及 CH 的分子机制尚不清楚。最近，越来越多的证据表明，长链非编码 RNA（lncRNA）在 CH 中发挥着重要作用。不同的 lncRNA 可以通过不同的机制促进或抑制 CH 的病理过程，而 lncRNA 表达的调节可以改善 CH。因此，CH 相关的 lncRNA 可能成为 CH 研究的一个新领域。
