Department of Cardiovascular Medicine, Graduate School of Medicine, Kyoto University.
Circ J. 2018 Apr 25;82(5):1231-1236. doi: 10.1253/circj.CJ-18-0169. Epub 2018 Mar 10.
Protein-coding genes account for less than 2% of the whole genome. However, the advances in RNA sequencing and genome-wide analysis have demonstrated that most of the genome is capable of being transcribed. Moreover, recent studies have suggested that long non-coding RNAs (lncRNAs) are critical regulators of gene expression and epigenesis in both physiological and disease states. Several lncRNAs are functionally involved in cardiovascular diseases and may be potential therapeutic targets. Here, we review the current strategies for the discovery of functional lncRNAs and recently discovered lncRNAs in the cardiovascular field, focusing on cardiac development, hypertrophy, heart failure, and atherosclerosis. We also discuss the therapeutic potentials of synthetic RNAs to modulate these lncRNAs and future directions in this research field.
蛋白质编码基因仅占整个基因组的不到 2%。然而，RNA 测序和全基因组分析的进展表明，大多数基因组都能够被转录。此外，最近的研究表明，长非编码 RNA（lncRNA）在生理和疾病状态下是基因表达和表观遗传的关键调节剂。一些 lncRNA 参与心血管疾病的功能，并可能成为潜在的治疗靶点。在这里，我们综述了目前发现心血管领域功能 lncRNA 的策略，重点介绍了心脏发育、肥大、心力衰竭和动脉粥样硬化。我们还讨论了合成 RNA 调节这些 lncRNA 的治疗潜力以及该研究领域的未来方向。
