Department of Cardiology, Chinese PLA General Hospital, Beijing 100853, China; Department of Cardiology, Xijing Hospital, Fourth Military Medical University, Xi'an, Shaanxi 710032, China.
Laboratory of the Animal Center, Academy of Military Medical Sciences, Beijing 100850, China.
Biochim Biophys Acta Mol Basis Dis. 2017 Aug;1863(8):2078-2084. doi: 10.1016/j.bbadis.2017.02.024. Epub 2017 Mar 1.
Long noncoding RNAs (lncRNAs) represent a category of noncoding RNAs with the potential for genetic and epigenetic regulations. As important regulators of gene expression, increasing evidence has proven that lncRNAs play a significant regulatory role in various cardiovascular pathologies. In particular, lncRNAs have been proved to be participating in gene regulatory mechanisms involved in heart growth and development that can be exploited to repair the injured adult heart. Furthermore, lncRNAs have been revealed as possible therapeutic targets for heart failure with different causes and in different stages. In the journey from a healthy heart to heart failure, lncRNAs have been shown to participate in almost every landmark of heart failure pathogenesis including ischemic injury, cardiac hypertrophy, and cardiac fibrosis. Furthermore, the manipulation of lncRNAs palliates the progression of heart failure by attenuating ischemic heart injury, cardiac hypertrophy and cardiac fibrosis, as well as facilitating heart regeneration and therapeutic angiogenesis. This review will highlight recent updates regarding the involvement of lncRNAs in cardiac hypertrophy and heart failure and their potential as novel therapeutic targets. This article is part of a Special Issue entitled: Genetic and epigenetic control of heart failure - edited by Jun Ren & Megan Yingmei Zhang.
长链非编码 RNA（lncRNA）是一类具有遗传和表观遗传调控潜能的非编码 RNA。作为基因表达的重要调控因子，越来越多的证据证明 lncRNA 在各种心血管病理中发挥着重要的调控作用。特别是，lncRNA 已被证明参与涉及心脏生长和发育的基因调控机制，可用于修复成年受损心脏。此外，lncRNA 已被揭示为不同病因和不同阶段心力衰竭的潜在治疗靶点。从健康心脏到心力衰竭的过程中，lncRNA 参与了心力衰竭发病机制的几乎每一个标志性事件，包括缺血损伤、心肌肥厚和心肌纤维化。此外，通过减轻缺血性心脏损伤、心肌肥厚和心肌纤维化，以及促进心脏再生和治疗性血管生成，lncRNA 的操纵可以缓解心力衰竭的进展。这篇综述将重点介绍 lncRNA 在心肌肥厚和心力衰竭中的作用以及它们作为新型治疗靶点的潜力的最新进展。本文是由 Jun Ren 和 Megan Yingmei Zhang 编辑的特刊：心力衰竭的遗传和表观遗传控制的一部分。
