Ano Yasuhisa, Ohya Rena, Kondo Keiji
Research Laboratories for Health Science & Food Technologies, Kirin Company Ltd.
J Nutr Sci Vitaminol (Tokyo). 2019;65(5):430-434. doi: 10.3177/jnsv.65.430.
The number of patients with mental illnesses, including depression, is rapidly increasing, and daily lifestyle is closely associated with the development of symptoms. Consequently, corrective measures, such as diet-based treatment for diseases, are receiving great attention. We previously showed that β-lactolin, a β-lactopeptide of glycine-threonine-tryptophan-tyrosine peptide, inhibits monoamine oxidase and improves memory impairment in mice, but the effects on depression have not been investigated. Here we showed that β-lactolin improved depression-like behavior via dopamine-D1-like receptor. Orally administered β-lactolin reduced immobility time in tail suspension test (TST). Pretreatment with SCH23390, dopamine D1-like receptor antagonist, attenuated the reduction in TST by β-lactolin. These effects were observed by the treatment with whey digest rich in β-lactolin. In addition, β-lactolin increased the levels of dopamine in the frontal cortex associated with the depression-like behavior. The present study suggests that supplements or nutraceutical compounds in whey digests (such as β-lactolin) show antidepressant-like effect.
包括抑郁症在内的精神疾病患者数量正在迅速增加，日常生活方式与症状的发展密切相关。因此，诸如基于饮食的疾病治疗等纠正措施正受到极大关注。我们之前表明，β-乳杆菌素（一种甘氨酸-苏氨酸-色氨酸-酪氨酸肽的β-乳糖肽）可抑制单胺氧化酶并改善小鼠的记忆障碍，但尚未研究其对抑郁症的影响。在此我们表明，β-乳杆菌素通过多巴胺D1样受体改善了抑郁样行为。口服β-乳杆菌素可减少悬尾试验（TST）中的不动时间。用多巴胺D1样受体拮抗剂SCH23390预处理可减弱β-乳杆菌素对TST的缩短作用。富含β-乳杆菌素的乳清消化物处理也观察到了这些效果。此外，β-乳杆菌素增加了与抑郁样行为相关的额叶皮质中的多巴胺水平。本研究表明，乳清消化物中的补充剂或营养化合物（如β-乳杆菌素）具有抗抑郁样作用。
