Fukuda T, Kanatome A, Takashima A, Tajima O, Umeda S, Ano Y
Takafumi Fukuda, KIRIN Central Research Institute, Kirin Holdings Company, Limited, 26-1, Muraoka-Higashi 2-chome. Fujisawa, Kanagawa 251-8555, Japan, Email:
J Nutr Health Aging. 2022;26(2):127-132. doi: 10.1007/s12603-022-1733-8.
Epidemiological studies have shown that consumption of dairy products reduces the risk of dementia and cognitive decline in older individuals. Tryptophan-tyrosine-related β-lactopeptides and their representative β-lactolin of glycine-threonine-tryptophan-tyrosine tetra-peptide have been identified as agents in dairy products, which improve cognitive function as well as memory function via the activation of the dopaminergic system in a mouse model of amnesia. Previous clinical trials have shown that supplementation with β-lactolin improves memory retrieval in healthy older adults. Specifically, β-lactolin improved the scores in some neuropsychological tests. However, the effects of β-lactolin on memory function have not been clarified.
The aim of this study was to evaluate the effect of β-lactolin on memory function using statistical methods.
We searched the Web of Science, Cochrane Library, and JDream III until November 2021 to identify relevant randomized controlled trials for integrated analysis.
Three randomized controlled trials evaluating the effect of β-lactolin on memory in healthy adults were selected for the integrated analysis. The results showed that the score of cued recall among the neuropsychological tests in the β-lactolin group was significantly higher than that in the placebo group (g=0.33; 95% CI: 0.10, 0.55). In addition, the total memory score was higher but this difference was not significant (g=0.17; 95% CI: -0.09, 0.43).
Taken together, these results suggest that supplementation with β-lactolin improves cued recall in healthy older adults.
流行病学研究表明，食用乳制品可降低老年人患痴呆症和认知能力下降的风险。色氨酸 - 酪氨酸相关的β - 内酰胺肽及其代表性的甘氨酸 - 苏氨酸 - 色氨酸 - 酪氨酸四肽β - 内酰胺林已被确定为乳制品中的成分，它们在失忆小鼠模型中通过激活多巴胺能系统来改善认知功能和记忆功能。先前的临床试验表明，补充β - 内酰胺林可改善健康老年人的记忆提取。具体而言，β - 内酰胺林提高了一些神经心理学测试的分数。然而，β - 内酰胺林对记忆功能的影响尚未明确。
本研究旨在使用统计方法评估β - 内酰胺林对记忆功能的影响。
我们检索了科学网、考克兰图书馆和JDream III直至2021年11月，以确定相关的随机对照试验进行综合分析。
选择三项评估β - 内酰胺林对健康成年人记忆影响的随机对照试验进行综合分析。结果显示，β - 内酰胺林组神经心理学测试中的线索回忆得分显著高于安慰剂组（g = 0.33；95%CI：0.10，0.55）。此外，总记忆得分较高，但差异不显著（g = 0.17；95%CI： - 0.09，0.43）。
综上所述，这些结果表明补充β - 内酰胺林可改善健康老年人的线索回忆。
