Zhang Yan, Fang Xiang-Ming, Chen Guo-Xun
Department of Gastroenterology, Affiliated Puren Hospital of Wuhan University of Science and Technology, Wuhan 430000, Hubei Province, China.
Department of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, United States.
World J Clin Cases. 2019 Oct 26;7(20):3168-3174. doi: 10.12998/wjcc.v7.i20.3168.
The use of low-dose aspirin (LDA) has been a common preventive measure to reduce the risk of cardiovascular events. This is attributed to aspirin's ability to inhibit platelet activation. On the other hand, the use of LDA in human subjects has been associated with the development of gastrointestinal injuries like ulcer and bleeding, especially for those sensitive subjects such as elder human subjects. This opinion review will summarize the recent clinical reports regarding the use of LDA and the development of gastrointestinal conditions in China. Based on these reports, it seems that the use of LDA is commonly associated with gastrointestinal injuries, and stopping its use leads to recovery in elderly subjects. Therefore, we would like to suggest that gastroduodenal health and conditions should be seriously taken into consideration when LDA is recommended to the elderly, or other alternative means to reduce the risk of cardiovascular events such as nutritional interventions should be suggested.
使用低剂量阿司匹林（LDA）一直是降低心血管事件风险的常见预防措施。这归因于阿司匹林抑制血小板活化的能力。另一方面，在人类受试者中使用LDA与溃疡和出血等胃肠道损伤的发生有关，尤其是对于老年等敏感受试者。这篇观点综述将总结中国近期关于LDA使用及胃肠道疾病发生情况的临床报告。基于这些报告，似乎LDA的使用通常与胃肠道损伤有关，而停用LDA会使老年受试者病情恢复。因此，我们建议，在向老年人推荐LDA时，应认真考虑胃十二指肠健康状况，或者应建议采用其他降低心血管事件风险的替代方法，如营养干预措施。
