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识别妊娠期阿片类药物与加巴喷丁共同暴露情况。

Identifying Co-Exposure to Opiates and Gabapentin During Pregnancy.

机构信息

Department of Pediatrics, Joan C. Edwards School of Medicine at Marshall University, Huntington, WV.

NICU, Hoops Family Children's Hospital at Cabell Huntington Hospital, Huntington, WV.

出版信息

J Pediatr. 2020 Feb;217:196-198. doi: 10.1016/j.jpeds.2019.09.029. Epub 2019 Oct 24.

DOI:10.1016/j.jpeds.2019.09.029
PMID:31668481
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7503060/
Abstract

Neonatal withdrawal can be difficult to treat in infants with co-exposure to opiates and gabapentin. Because maternal self-report can underestimate exposures, we evaluated the effect of universal toxicology screening for gabapentin. Identification of co-exposure to opiates and gabapentin increased after implementation of toxicology screening, with implications for improved neonatal care.

摘要

新生儿戒断症状在同时接触阿片类药物和加巴喷丁的婴儿中较难治疗。由于母体自我报告可能会低估暴露情况，因此我们评估了对加巴喷丁进行普遍毒物筛查的效果。毒物筛查实施后，阿片类药物和加巴喷丁共同暴露的检出率增加，这对改善新生儿护理具有重要意义。

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本文引用的文献

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Addiction. 2019 Sep;114(9):1683-1693. doi: 10.1111/add.14651. Epub 2019 Jun 19.
2
Public Health Surveillance of Prenatal Opioid Exposure in Mothers and Infants.母亲和婴儿中产前阿片类药物暴露的公共卫生监测。
Pediatrics. 2019 Mar;143(3). doi: 10.1542/peds.2018-3801. Epub 2019 Jan 17.
3
Pharmacologic Treatment of Opioid Use Disorder: a Review of Pharmacotherapy, Adjuncts, and Toxicity.阿片类物质使用障碍的药物治疗：药物疗法、辅助治疗及毒性综述
J Med Toxicol. 2018 Dec;14(4):306-322. doi: 10.1007/s13181-018-0685-1. Epub 2018 Oct 30.
4
Risk of neonatal drug withdrawal after intrauterine co-exposure to opioids and psychotropic medications: cohort study.宫内同时暴露于阿片类药物和精神药物后新生儿药物戒断的风险：队列研究
BMJ. 2017 Aug 2;358:j3326. doi: 10.1136/bmj.j3326.
5
Appropriate Use of Drug Testing in Clinical Addiction Medicine.药物检测在临床成瘾医学中的合理应用。
J Addict Med. 2017 May/Jun;11(3):163-173. doi: 10.1097/ADM.0000000000000323.
6
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7
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