双侧乳腺癌的预后。首次和第二次原发性肿瘤之间时间间隔的影响。
Prognosis in bilateral breast cancer. Effects of time interval between first and second primary tumours.
作者信息
Holmberg L, Adami H O, Ekbom A, Bergström R, Sandström A, Lindgren A
机构信息
Department of Surgery, University Hospital, Uppsala, Sweden.
出版信息
Br J Cancer. 1988 Aug;58(2):191-4. doi: 10.1038/bjc.1988.191.
Survival rates for 67 women with bilateral breast cancer were compared to those for 1282 women with unilateral disease in a follow-up of 1349 women participating in a population-based study. Relative survival at 8 years of follow-up was 69% for women with unilateral disease as compared to 53% for women with bilateral cancer. When possible confounding histopathological differences--data about which were prospectively collected--and age were adjusted for in a multivariate analysis, the relative hazard rate was significantly higher for women with bilateral versus unilateral breast cancer (P = 0.006). The impact of interval time between the two primaries was analysed and a roughly two-fold higher hazard rate was seen for synchronous cancers with regularly falling risk for increasing interval times. This trend was however not statistically significant. The results indicate that the two tumours contribute independently to the patient's excess risk of dying and thus occur as two seemingly biologically unrelated events with respect to the tumour-host relationship and metastatic behaviour.
在一项基于人群的研究中，对1349名女性进行随访，比较了67例双侧乳腺癌女性与1282例单侧乳腺癌女性的生存率。单侧乳腺癌女性在随访8年时的相对生存率为69%，而双侧乳腺癌女性为53%。在多变量分析中，对可能存在的混杂组织病理学差异（前瞻性收集相关数据）和年龄进行调整后，双侧乳腺癌女性的相对风险率显著高于单侧乳腺癌女性（P = 0.006）。分析了两个原发性肿瘤之间的间隔时间的影响，同步性癌症的风险率大约高出两倍，且随着间隔时间增加风险有规律地下降。然而，这种趋势在统计学上并不显著。结果表明，这两个肿瘤独立地导致患者额外的死亡风险，因此就肿瘤-宿主关系和转移行为而言，它们似乎是两个生物学上不相关的事件。
Zotero 插件