Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran; Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Department of Clinical Biochemistry, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Gene. 2020 Feb 5;726:144132. doi: 10.1016/j.gene.2019.144132. Epub 2019 Dec 3.
The NF-κB signaling pathway is a key regulator of CRC cell proliferation, apoptosis, angiogenesis, inflammation, metastasis, and drug resistance. Over-activation of the NF-κB pathway is a feature of colorectal cancer (CRC). While new combinatorial treatments have improved overall patient outcome; quality of life, cost of care, and patient survival rate have seen little improvement. Suppression of the NF-κB signaling pathway using biological or specific pharmacological inhibitors is a potential therapeutic approach in the treatment of colon cancer. This review summarizes the regulatory role of NF-κB signaling pathway in the pathogenesis of CRC for a better understanding and hence a better management of the disease.
NF-κB 信号通路是 CRC 细胞增殖、凋亡、血管生成、炎症、转移和耐药的关键调节剂。NF-κB 通路的过度激活是结直肠癌（CRC）的一个特征。虽然新的联合治疗方案改善了整体患者预后，但生活质量、治疗成本和患者生存率几乎没有改善。使用生物或特定药理学抑制剂抑制 NF-κB 信号通路是治疗结肠癌的一种潜在治疗方法。本文综述了 NF-κB 信号通路在 CRC 发病机制中的调控作用，以期更好地理解该疾病，从而更好地进行管理。
