Department of Ophthalmology, College of Medicine, Seoul National University, Seoul, Korea.
Retinal Degeneration Research Laboratory, Seoul National University Hospital Biomedical Research Institute, Seoul, South Korea.
Ocul Immunol Inflamm. 2021 Feb 17;29(2):388-395. doi: 10.1080/09273948.2019.1677918. Epub 2019 Oct 31.
: To evaluate subfoveal choroidal thickness (SCT) changes and ocular inflammation after pars plana vitrectomy (PPV) in Vogt-Koyanagi-Harada (VKH) disease.: We analyzed best-corrected visual acuity (BCVA), ocular inflammation, complications, and SCT in 17 eyes of 14 patients with VKH disease who underwent PPV and had ≥12-month follow-up. Main surgical indications included vitreous opacity, epiretinal membrane, and macular hole.: Mean BCVA showed significant improvement at all time-points after PPV. Mean SCT significantly increased up until 3 months after PPV ( = .001), but returned to baseline at 12 months and was lower than baseline at the final visit ( = .025). Mean acute uveitis relapse rate decreased after PPV ( = .008). SCT increase was greater in the nine eyes with postoperative uveitis recurrence than in those without ( = .043).: Vision improved after PPV in patients with VKH disease. SCT increase in the early postoperative period was associated with uveitis recurrence during follow-up, suggesting that vitrectomy may induce choroiditis after PPV in VKH.
: 评估 Vogt-小柳-原田（VKH）病行玻璃体切除术（PPV）后中心凹下脉络膜厚度（SCT）的变化和眼内炎症。: 我们分析了 14 例 VKH 病患者 17 只眼接受 PPV 并随访≥12 个月的最佳矫正视力（BCVA）、眼内炎症、并发症和 SCT。主要手术适应证包括玻璃体混浊、视网膜内膜和黄斑裂孔。: 术后所有时间点 BCVA 均有显著改善。SCT 均值在 PPV 后 3 个月显著增加（=.001），但在 12 个月时恢复到基线，在最后一次随访时低于基线（=.025）。急性葡萄膜炎复发率在 PPV 后降低（=.008）。在有术后葡萄膜炎复发的 9 只眼中，SCT 增加大于无复发的眼中（=.043）。: VKH 病患者行 PPV 后视力改善。术后早期 SCT 增加与随访期间葡萄膜炎复发有关，提示 PPV 后玻璃体切除术可能会诱发 VKH 脉络膜炎。
