在复发性前葡萄膜炎发作期间，Vogt-小柳原田病患者的脉络膜血管指数降低，脉络膜厚度增加。
The Choroidal Vascularity Index Decreases and Choroidal Thickness Increases in Vogt-Koyanagi-Harada Disease Patients During a Recurrent Anterior Uveitis Attack.
机构信息
a The First Affiliated Hospital of Chongqing Medical University, Chongqing Key Laboratory of Ophthalmology and Chongqing Eye Institute , Chongqing , P.R. China.
b University Eye Clinic Maastricht , Ophthalmology Department, Maastricht , The Netherlands.
出版信息
Ocul Immunol Inflamm. 2018;26(8):1237-1243. doi: 10.1080/09273948.2017.1343357. Epub 2017 Sep 15.
PURPOSE
To measure changes in the choroidal vascularity index (CVI) in chronic Vogt-Koyanagi-Harada (VKH) disease during a recurrent anterior uveitis attack.
METHODS
Forty VKH patients and 40 normal controls were included in this study. Choroidal images were recorded before and during a recurrent anterior uveitis attack, as well as after appropriate treatment. CVI was measured by the binarization technique using ImageJ software (Bethesda, MD).
RESULTS
The CVI was 0.75 ± 0.09 in quiescent VKH patients, which was significantly higher compared to healthy controls (0.70 ± 0.05, p ＜ 0.0001). The CVI significantly decreased to 0.72 ± 0.09 when granulomatous anterior uveitis appeared in these patients. However, it returned to 0.75 ± 0.08 after uveitis resolved.
CONCLUSIONS
A significant decrease of the CVI occurred during recurrent anterior uveitis in chronic VKH. CVI may provide a novel parameter to guide the treatment of VKH disease.
目的
测量慢性 Vogt-小柳-原田（Vogt-Koyanagi-Harada，VKH）病在复发性前葡萄膜炎发作期间脉络膜血管指数（CVI）的变化。
方法
本研究纳入了 40 例 VKH 患者和 40 名正常对照者。在复发性前葡萄膜炎发作前、发作期间以及适当治疗后，对脉络膜图像进行了记录。使用 ImageJ 软件（马里兰州贝塞斯达）通过二值化技术测量 CVI。
结果
在静止期 VKH 患者中，CVI 为 0.75 ± 0.09，明显高于健康对照组（0.70 ± 0.05，p ＜ 0.0001）。当这些患者出现肉芽肿性前葡萄膜炎时，CVI 显著下降至 0.72 ± 0.09。然而，当葡萄膜炎消退后，CVI 恢复至 0.75 ± 0.08。
结论
慢性 VKH 中复发性前葡萄膜炎期间 CVI 显著下降。CVI 可能为 VKH 疾病的治疗提供新的参数。
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