Vogt-小柳原田病慢性期患者的脉络膜中心凹下厚度与前节炎症的相关性。
Correlation between Subfoveal Choroidal Thickness and Anterior Segment Inflammation in Patients with Chronic Stage of Vogt-Koyanagi-Harada Disease.
机构信息
Department of Ophthalmology, Hospital Universitario Austral, Buenos Aires, Argentina.
Department of Ophthalmology, Byers Eye Institute, Stanford University, Palo Alto, California, USA.
出版信息
Ocul Immunol Inflamm. 2022 Apr 3;30(3):646-651. doi: 10.1080/09273948.2020.1826533. Epub 2020 Oct 6.
PURPOSE
To correlate changes in subfoveal choroidal thickness (SCT) with the degree of anterior inflammatory activity in chronic Vogt-Koyanagi-Harada (VKH) disease.
METHODS
Anterior segment inflammation was assessed using SUN anterior chamber cell grading criteria, and SCT was measured using EDI-OCT in patients with VKH at multiple visits. ANOVA was used to compare the mean SCT for each anterior chamber cell grade. Regression analysis was used to correlate the anterior segment cell grade and the SCT.
RESULTS
14 patients were included in the study. A total of 432 data points consisting of SCT and anterior segment cell values were analyzed. ANOVA demonstrated significant difference between the mean SCT for different anterior chamber cell grades ( < .0001). Regression analysis demonstrated significant correlation between SCT and grade of anterior chamber cells (R = 0.37, < .001).
CONCLUSIONS
Chronic VKH is characterized by a dynamic change in SCT that correlates with anterior segment inflammatory activity.
目的
探讨慢性 Vogt-小柳-原田病（VKH）患者黄斑中心凹下脉络膜厚度（SCT）的变化与前部炎症活动程度的相关性。
方法
采用 SUN 前房细胞分级标准评估前部炎症，并用 EDI-OCT 在多次就诊时测量 VKH 患者的 SCT。采用方差分析比较每个前房细胞分级的平均 SCT。采用回归分析将前房细胞分级与 SCT 进行相关性分析。
结果
本研究纳入 14 例患者。共分析了 432 个 SCT 和前房细胞值的数据点。方差分析显示不同前房细胞分级的平均 SCT 之间存在显著差异（ < 0.0001）。回归分析显示 SCT 与前房细胞分级之间存在显著相关性（R=0.37， < 0.001）。
结论
慢性 VKH 的特征是 SCT 发生动态变化，与前部炎症活动相关。
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