嗜铬细胞瘤和副神经节瘤指南
A Guide to Pheochromocytomas and Paragangliomas.
作者信息
Guilmette Julie, Sadow Peter M
机构信息
Department of Pathology, Charles-Lemoyne Hospital, Sherbrooke University Affiliated Health Care Center, 3120 Boulevard Taschereau, Greenfield Park, Quebec J4V 2H1, Canada.
Department of Pathology, Massachusetts General Hospital, Harvard Medical School, 55 Fruit Street, Boston, MA 02114-2696, USA.
出版信息
Surg Pathol Clin. 2019 Dec;12(4):951-965. doi: 10.1016/j.path.2019.08.009. Epub 2019 Sep 28.
Abstract
Pheochromocytomas and extra-adrenal paragangliomas are rare neuroendocrine neoplasms with characteristic histologic and immunohistochemical features. These tumors can arise in several anatomic locations, necessitating that their diagnostic recognition extends beyond the realm of endocrine disorders. A practical and reproducible risk stratification system for these tumors is still in development. In this rapidly evolving era of molecular medicine, it is essential for pathologists to equip themselves with a framework for understanding the classification of paragangliomas and pheochromocytomas and be informed of how they might advise their colleagues with regard to prognostication and appropriate follow-up.
摘要
嗜铬细胞瘤和肾上腺外副神经节瘤是罕见的神经内分泌肿瘤，具有特征性的组织学和免疫组化特征。这些肿瘤可发生于多个解剖部位，因此其诊断识别超出了内分泌疾病的范畴。针对这些肿瘤的实用且可重复的风险分层系统仍在开发中。在这个分子医学快速发展的时代，病理学家必须具备一个理解副神经节瘤和嗜铬细胞瘤分类的框架，并了解如何就预后和适当的随访向同事提供建议。
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