Nanobiophysics Group, University of Twente, 7522, NB, Enschede, the Netherlands.
Nanobiophysics Group, University of Twente, 7522, NB, Enschede, the Netherlands.
Arch Biochem Biophys. 2019 Nov 30;677:108163. doi: 10.1016/j.abb.2019.108163. Epub 2019 Oct 29.
Membrane proteins control and shape membrane trafficking processes. The role of protein structure in shaping cellular membranes is well established. However, a significant fraction of membrane proteins is disordered or contains long disordered regions. It becomes more and more clear that these disordered regions contribute to the function of membrane proteins. While the fold of a structured protein is essential for its function, being disordered seems to be a crucial feature of membrane bound intrinsically disordered proteins and protein regions. Here we outline the motifs that encode function in disordered proteins and discuss how these functional motifs enable disordered proteins to modulate membrane properties. These changes in membrane properties facilitate and regulate membrane trafficking processes which are highly abundant in eukaryotes.
膜蛋白控制和塑造膜运输过程。蛋白质结构在塑造细胞膜中的作用已得到充分证实。然而，相当一部分膜蛋白是无序的或含有长的无序区域。越来越明显的是，这些无序区域有助于膜蛋白的功能。虽然结构蛋白的折叠对于其功能至关重要，但无序似乎是膜结合固有无序蛋白和蛋白区域的关键特征。在这里，我们概述了无序蛋白中编码功能的模体，并讨论了这些功能模体如何使无序蛋白能够调节膜特性。这些膜特性的变化促进和调节了真核生物中高度丰富的膜运输过程。
