Department of Otorhinolaryngology Head and Neck Surgery, Chinese People Liberation Army 306th Hospital, Beijing, China.
State Environmental Protection Key Laboratory of Environmental Sense Organ Stress and Health, Beijing, China.
Sci Rep. 2019 Oct 31;9(1):15744. doi: 10.1038/s41598-019-52349-5.
Endoscopic grading of gastroesophageal flap valve (GEFV) is simple and reproducible and offers useful information for reflux activity. To investigate the potential correlation between GEFV grading and reflux finding score (RFS) in patients with laryngopharyngeal reflux disease (LPRD), 225 consecutive Patients with suspected LPRD who underwent both routine upper gastrointestinal endoscopy and laryngoscope were enrolled in our study. Patients with a RFS of more than 7 were diagnosed with LPRD. The GEFV was graded as I through IV according to Hill's classification and was classified into two groups: normal GEFV group (grades I and II) and the abnormal GEFV group (grades III and IV). The percent of GEFV grades I to IV was 39.1%, 39.1%, 12.4%, and 9.3%, respectively. Age was significantly related to an abnormal GEFV (p = 0.002). Gender, BMI, smoke and alcohol were not related to GEFV grade. Fifty-one patients (22.67%) had positive RFS. Reflux finding scores were higher in GEFV grades III and IV than I and II (p < 0.05). Endoscopic grading of GEFV is well correlated with reflux finding score in patients with LPRD. This is a simple and useful technique that provides valuable diagnostic information of LPRD.
胃食管瓣（GEFV）内镜分级简单且可重复，为反流活动提供了有用的信息。为了研究胃食管瓣分级（GEFV）与喉咽反流病（LPRD）患者反流发现评分（RFS）之间的潜在相关性，我们对 225 例疑似 LPRD 且同时接受常规上消化道内镜和喉镜检查的患者进行了研究。RFS 大于 7 的患者被诊断为 LPRD。根据 Hill 分类，GEFV 分级为 I 至 IV 级，并分为正常 GEFV 组（I 级和 II 级）和异常 GEFV 组（III 级和 IV 级）。GEFV 分级 I 至 IV 级的百分比分别为 39.1%、39.1%、12.4%和 9.3%。年龄与异常 GEFV 显著相关（p=0.002）。性别、BMI、吸烟和饮酒与 GEFV 分级无关。51 例（22.67%）患者 RFS 阳性。GEFV 分级 III 和 IV 级的 RFS 高于 I 和 II 级（p<0.05）。在 LPRD 患者中，GEFV 内镜分级与反流发现评分密切相关。这是一种简单而有用的技术，为 LPRD 提供了有价值的诊断信息。
