Rufin Marc A, Ngo Bryan Khai D, Barry Mikayla E, Page Vanessa M, Hawkins Melissa L, Stafslien Shane J, Grunlan Melissa A
Department of Biomedical Engineering, Texas A&M University, College Station, TX, USA.
Center for Nanoscale Science and Engineering, North Dakota State University, Fargo, ND, USA.
Green Mater. 2017 Mar;5(1):4-13. doi: 10.1680/jgrma.16.00013. Epub 2017 Jul 20.
Surface modifying additives (SMAs), which may be readily blended into silicones to improve anti-fouling behavior, must have excellent surface migration potential and must not leach into the aqueous environment. In this work, we evaluated the efficacy of a series of poly(ethylene oxide) (PEO)-based SMA amphiphiles which varied in terms of crosslinkability, siloxane tether length (m) and diblock versus triblock architectures. Specifically, crosslinkable, diblock PEO-silane amphiphiles with two oligodimethylsiloxane (ODMS) tether lengths [(EtO)Si-(CH)-ODMS -PEO, = 13 and 30] were compared to analogous non-crosslinkable, diblock (H-Si-ODMS -PEO) and triblock (PEO-ODMS -PEO) SMAs. Prior to water conditioning, while all modified silicone coatings exhibited a high degree of water-driven surface restructuring, that prepared with the non-crosslinkable diblock SMA ( = 13) was the most hydrophilic. After conditioning, all modified silicone coatings were similarly hydrophilic and remained highly protein resistant, with the exception of PEO-ODMS -PEO. Notably, despite twice the PEO content, triblock SMAs were not superior to diblock SMAs. For diblock SMAs, it was shown that water uptake and leaching were also similar whether or not the SMA was crosslinkable.
可轻松混入有机硅以改善防污性能的表面改性添加剂（SMA），必须具有出色的表面迁移潜力，且不得渗入水环境。在本研究中，我们评估了一系列基于聚环氧乙烷（PEO）的SMA两亲物的功效，这些两亲物在可交联性、硅氧烷连接链长度（m）以及二嵌段与三嵌段结构方面存在差异。具体而言，将具有两种低聚二甲基硅氧烷（ODMS）连接链长度[（EtO）Si - （CH） - ODMS - PEO， = 13和30]的可交联二嵌段PEO - 硅烷两亲物与类似的不可交联二嵌段（H - Si - ODMS - PEO）和三嵌段（PEO - ODMS - PEO）SMA进行了比较。在水调节之前，虽然所有改性有机硅涂层都表现出高度的水驱动表面重构，但用不可交联二嵌段SMA（ = 13）制备的涂层亲水性最强。调节后，除了PEO - ODMS - PEO外，所有改性有机硅涂层的亲水性相似，并且仍然具有高度的抗蛋白质性能。值得注意的是，尽管三嵌段SMA的PEO含量是二嵌段SMA的两倍，但其性能并不优于二嵌段SMA。对于二嵌段SMA，研究表明，无论SMA是否可交联，其吸水率和浸出率也相似。
