Department of Materials Science and Engineering, Texas A&M University, College Station, TX 77843, USA.
Department of Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
J Mater Chem B. 2022 Apr 20;10(16):3064-3072. doi: 10.1039/d2tb00213b.
Silicone intraocular lenses (IOLs) that resist lens epithelial cell (LEC) growth would greatly improve patient outcomes. Herein, amphiphilic surface modifying additives (SMAs) were incorporated into an IOL-type diphenyl silicone to reduce LEC growth without compromising opto-mechanical properties. The SMAs were poly(ethylene oxide)-silane amphiphiles (PEO-SAs) [H-Si-ODMS--PEO-OCH], comprised of a PEO segment and siloxane tether of varying lengths ( = 0, 13, and 30). These three SMAs were each blended into the addition cure diphenyl silicone at varying concentrations (5, 10, 15, 20, and 25 μmol g) wherein the wt% of PEO was maintained for all SMAs at a given molar concentration. The chemical crosslinking and subsequent retention of SMAs in modified silicones was confirmed. Key material properties were assessed following equilibration in both air and aqueous environments. Silicones modified with SMAs having longer tethers ( = 13 and 30) underwent rapid and substantial water-driven restructuring of PEO to the surface to form highly hydrophilic surfaces, especially as SMA concentration increased. The % transmittance was also maintained for silicones modified with these particular SMAs. The moduli of the modified silicones were largely unchanged by the SMA and remained in the typical range for silicone IOLs. When the three SMAs were introduced at the highest concentration, modified silicones remained non-cytotoxic and LEC count and associated alpha-smooth muscle actin (α-SMA) expression decreased with increasing tether length. These results demonstrate the potential of silicones modified with PEO-SA SMAs to produce LEC-resistant IOLs.
硅酮眼内透镜（IOL）能抑制晶状体上皮细胞（LEC）的生长，这将极大地改善患者的治疗效果。在此，将双亲性表面改性添加剂（SMA）掺入到 IOL 型二苯基硅酮中，以减少 LEC 的生长，同时又不影响光机械性能。SMA 为聚（环氧乙烷）-硅烷双亲性化合物（PEO-SA）[H-Si-ODMS--PEO-OCH]，由 PEO 段和不同长度的硅氧烷键组成（ = 0、13 和 30）。这三种 SMA 分别以不同浓度（5、10、15、20 和 25 μmol g）混合到加成固化二苯基硅酮中，其中所有 SMA 的 PEO 重量%保持在给定摩尔浓度下。证实了化学交联和随后改性硅酮中 SMA 的保留。在空气和水两种环境中平衡后，评估了关键材料性能。具有较长键（ = 13 和 30）的 SMA 改性的硅酮经历了快速和实质性的水驱动 PEO 向表面的重排，以形成高度亲水的表面，尤其是当 SMA 浓度增加时。PEO-SA SMA 改性的硅酮的透光率也得以维持。改性硅酮的模量受 SMA 的影响不大，仍保持在硅酮 IOL 的典型范围内。当将三种 SMA 以最高浓度引入时，改性硅酮仍保持非细胞毒性，并且随着键长的增加，LEC 计数和相关的α-平滑肌肌动蛋白（α-SMA）表达减少。这些结果表明，PEO-SA SMA 改性硅酮具有产生抗 LEC 的 IOL 的潜力。
