Kaysheva Anna L, Stepanov Alexander A, Kopylov Artur T, Butkova Tatiana V, Pleshakova Tatyana, Ryabtsev Vasily V, Iourov Ivan Yu, Vorsanova Svetlana G, Ivanov Yuri D
Institute of Biomedical Chemistry, Russia.
Mental Health Research Centre, Russia.
Data Brief. 2019 Sep 25;27:104558. doi: 10.1016/j.dib.2019.104558. eCollection 2019 Dec.
Protein profiles of 13 serum samples from children with autism spectrum disorders (ASD) and 11 serum samples from healthy volunteers was obtained using panoramic ultra-high resolution mass spectrometry. The analysis of measurements was performed using the proteomics search engine. We identified a group of 74 proteins which we term a "protein fingerprint" specific for serum samples collected from children with autism. Components of the protein fingerprint are involved in hemostasis maintenance including biological regulation, the response to stimulus, regulation of metabolism, and proteins of the immune system.
使用全景超高分辨率质谱法获得了13份自闭症谱系障碍（ASD）儿童的血清样本和11份健康志愿者的血清样本的蛋白质谱。使用蛋白质组学搜索引擎对测量结果进行分析。我们鉴定出一组74种蛋白质，我们将其称为自闭症儿童血清样本特有的“蛋白质指纹”。蛋白质指纹的成分参与止血维持，包括生物调节、对刺激的反应、代谢调节以及免疫系统的蛋白质。
