Nahanni Celina, Nadler Ashlie, Nathens Avery B
Department of Surgery, University of Toronto, Toronto, Ontario, Canada.
Surgery, Sunnybrook Health Sciences Centre, Toronto, Ontario, Canada.
Trauma Surg Acute Care Open. 2019 Sep 23;4(1):e000328. doi: 10.1136/tsaco-2019-000328. eCollection 2019.
Opioid administration in postoperative patients has contributed to the opioid crisis by increasing the load of opioids available in the community. Implementation of evidence-based practices is key to optimizing the use of opioids for acute pain control. This study aims to characterize the administration and prescribing practices after emergency laparoscopic general surgery procedures with the goal of identifying areas for improvement.
A retrospective chart review of 200 patients undergoing emergency laparoscopic appendectomies and cholecystectomies was conducted for a 2-year period at a single institution. Eligible patients were opioid-naïve adults admitted through the emergency department. Opioid administration and discharge prescriptions were converted to oral morphine equivalents (OME), and analyzed and compared with published literature and local guidelines.
Opioid analgesia was provided as needed to 69% of patients in hospital with average dosing of 26.7 OME/day; comparatively, 99.5% of patients received prescriptions for opioids on discharge at an average dosing of 61.7 OME/day. The average dosing in the discharge prescriptions was not correlated with in-hospital needs (Pearson=-0.04; p=0.56); and higher narcotic doses were associated with combination opioid prescriptions compared with separate opioid prescriptions (73.8 (1.90) vs. 50.1 (1.90) OME/day; p<0.01). This difference was driven by the combination medication, Percocet.
In the immediate postoperative period, most patients were managed in hospital with opioid analgesia dosages that fell within guidelines. Nearly all patients were provided with prescriptions for opioids on discharge, these prescriptions both exceeded local guidelines and were not correlated with in-hospital narcotic needs or pain scores.
Level 3 retrospective cohort study.
术后患者使用阿片类药物增加了社区中阿片类药物的可用量,从而加剧了阿片类药物危机。实施循证实践是优化使用阿片类药物控制急性疼痛的关键。本研究旨在描述急诊腹腔镜普通外科手术后的用药和处方情况,以确定可改进的领域。
在一家机构对200例行急诊腹腔镜阑尾切除术和胆囊切除术的患者进行了为期2年的回顾性病历审查。符合条件的患者为通过急诊科入院的未使用过阿片类药物的成年人。将阿片类药物的使用情况和出院处方转换为口服吗啡当量(OME),并与已发表的文献和当地指南进行分析比较。
69%的住院患者根据需要接受了阿片类镇痛治疗,平均剂量为26.7 OME/天;相比之下,99.5%的患者出院时接受了阿片类药物处方,平均剂量为61.7 OME/天。出院处方中的平均剂量与住院期间的需求无关(Pearson相关系数=-0.04;p=0.56);与单独的阿片类药物处方相比,联合阿片类药物处方的麻醉剂量更高(73.8(1.90)与50.1(1.90)OME/天;p<0.01)。这种差异是由复方药物扑热息痛加羟考酮引起的。
在术后即刻,大多数患者在医院接受的阿片类镇痛剂量符合指南。几乎所有患者出院时都获得了阿片类药物处方,这些处方既超出了当地指南,也与住院期间的麻醉需求或疼痛评分无关。
3级回顾性队列研究。