Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, MD.
Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University School of Medicine, Baltimore, MD.
J Am Coll Surg. 2018 Oct;227(4):411-418. doi: 10.1016/j.jamcollsurg.2018.07.659. Epub 2018 Aug 14.
One in 16 surgical patients prescribed opioids becomes a long-term user. Overprescribing opioids after surgery is common, and the lack of multidisciplinary procedure-specific guidelines contributes to the wide variation in opioid prescribing practices. We hypothesized that a single-institution, multidisciplinary expert panel can establish consensus on ideal opioid prescribing for select common surgical procedures.
We used a 3-step modified Delphi method involving a multidisciplinary expert panel of 6 relevant stakeholder groups (surgeons, pain specialists, outpatient surgical nurse practitioners, surgical residents, patients, and pharmacists) to develop consensus ranges for outpatient opioid prescribing at the time of discharge after 20 common procedures in 8 surgical specialties. Prescribing guidelines were developed for opioid-naïve adult patients without chronic pain undergoing uncomplicated procedures. The number of opioid tablets was defined using oxycodone 5 mg oral equivalents.
For all 20 surgical procedures reviewed, the minimum number of opioid tablets recommended by the panel was 0. Ibuprofen was recommended for all patients unless medically contraindicated. The maximum number of opioid tablets varied by procedure (median 12.5 tablets), with panel recommendations of 0 opioid tablets for 3 of 20 (15%) procedures, 1 to 15 opioid tablets for 11 of 20 (55%) procedures, and 16 to 20 tablets for 6 of 20 (30%) procedures. Overall, patients who had the procedures voted for lower opioid amounts than surgeons who performed them.
Procedure-specific prescribing recommendations may help provide guidance to clinicians who are currently overprescribing opioids after surgery. Multidisciplinary, patient-centered consensus guidelines for more procedures are feasible and may serve as a tool in combating the opioid crisis.
接受阿片类药物处方的患者中有 16 分之一成为长期使用者。手术后过度开具阿片类药物的情况很常见,缺乏多学科特定程序指南导致阿片类药物处方实践存在广泛差异。我们假设,一个单一机构的多学科专家小组可以就选定常见手术的理想阿片类药物处方达成共识。
我们使用了三步法修改后的 Delphi 方法,涉及 6 个相关利益相关者群体(外科医生、疼痛专家、门诊外科护士从业者、外科住院医师、患者和药剂师)的多学科专家小组,以确定 8 个外科专业的 20 种常见手术中出院时门诊阿片类药物处方的共识范围。为没有慢性疼痛且接受简单手术的阿片类药物初治成年患者制定了处方指南。使用羟考酮 5 毫克口服等效物定义了阿片类药物片剂的数量。
对于所有 20 种手术程序,专家组推荐的最低阿片类药物片剂数量为 0。除非医学上禁忌,否则建议所有患者使用布洛芬。阿片类药物片剂的最大数量因程序而异(中位数为 12.5 片),专家组建议的 20 项手术中的 3 项(15%)无阿片类药物片剂,11 项(55%)为 1 至 15 片阿片类药物片剂,6 项(30%)为 16 至 20 片阿片类药物片剂。总体而言,接受手术的患者比进行手术的外科医生投票赞成的阿片类药物数量更少。
特定程序的处方建议可能有助于为目前手术后过度开具阿片类药物的临床医生提供指导。针对更多程序的多学科、以患者为中心的共识指南是可行的,并可能成为应对阿片类药物危机的工具。