来自[具体来源未给出]的倍半萜类化合物及其在RAW264.7细胞中的一氧化氮生成抑制活性。
Sesquiterpenoids from and their NO production inhibitory activity in RAW264.7 cells.
作者信息
Xue Gui-Min, Xue Jin-Feng, Zhao Chen-Guang, Zhao Zhen-Zhu, Sun Yan-Jun, Du Kun, Li Han-Wei, Feng Wei-Sheng
机构信息
College of Pharmacy, Henan University of Traditional Chinese Medicine, Zhengzhou, China.
Collaborative Innovation Center for Respiratory Disease Diagnosis and Treatment and Chinese Medicine Development of Henan Province, Zhengzhou, China.
出版信息
Nat Prod Res. 2021 Sep;35(17):2887-2894. doi: 10.1080/14786419.2019.1680665. Epub 2019 Nov 1.
Investigation into the chemical diversity of led to the discovery of two new (, ) and four known (, -) sesquiterpenoids. The new structures were determined extensive spectroscopic data, including IR, UV, MS, and NMR, and the absolute configurations of these compounds were elucidated by calculated ECD method. All isolates were tested for their inhibitory activity against NO production in RAW 264.7 macrophages, and the isolated sesquiterpenoids exhibited NO production inhibitory activity with IC values ranging from 1.91 to 36.52 μM.
对[具体物质]化学多样性的研究导致发现了两种新的（[新化合物名称1]，[新化合物名称2]）和四种已知的（[已知化合物名称1]，[已知化合物名称2]，[已知化合物名称3]，[已知化合物名称4]）倍半萜类化合物。通过广泛的光谱数据，包括红外光谱（IR）、紫外光谱（UV）、质谱（MS）和核磁共振谱（NMR）确定了新结构，并通过计算电子圆二色谱（ECD）方法阐明了这些化合物的绝对构型。对所有分离物进行了针对RAW 264.7巨噬细胞中一氧化氮（NO）产生的抑制活性测试，分离得到的倍半萜类化合物表现出NO产生抑制活性，IC值范围为1.91至36.52μM。
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