从西藏土壤中分离到的一种产生的多烯羧酸。

Polyene Carboxylic Acids from a sp. Isolated from Tibet Soil.

机构信息

Marine College, Shandong University, Weihai 264209, China.

Institutional Center for Shared Technologies and Facilities, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.

出版信息

Molecules. 2023 Mar 12;28(6):2579. doi: 10.3390/molecules28062579.

DOI:10.3390/molecules28062579

PMID:36985551

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10054270/

Abstract

Six new polyene carboxylic acids named serpentemycins E-J (-), together with three known analogs (-), were isolated from the fermentation medium of sp. TB060207, which was isolated from arid soil collected from Tibet, China. The structures of the new compounds were elucidated mainly on the basis of HR-ESI-MS and NMR spectroscopic analyses. The inhibitory activities of compounds - against NO production in LPS-activated RAW264.7 cells were evaluated. Compound has an inhibition rate of 87.09% to 60.53% at concentrations ranging from 5.0 to 40.0 µM.

摘要

从中国西藏干旱土壤中分离得到的 sp. TB060207 的发酵液中分离得到了 6 个新的多烯羧酸类化合物，命名为 serpentemycins E-J (-)，同时还分离得到了 3 个已知类似物 (-)。新化合物的结构主要根据高分辨电喷雾电离质谱（HR-ESI-MS）和核磁共振波谱（NMR）分析来阐明。评估了化合物 - 对 LPS 激活的 RAW264.7 细胞中 NO 产生的抑制活性。在 5.0 至 40.0 µM 的浓度范围内，化合物对 60.53% 至 87.09%的 NO 产生具有抑制作用。