Liu Bing, Chen Ning, Xu Ying, Zhang Jia-Wei, Sun Yuan, Zhao Li-Zhu, Ji Yu-Bin
Pharmaceutical Engineering Technology Research Center, Harbin University of Commerce, Harbin, China.
Postdoctoral Center of Chinese Pharmacy, Harbin University of Commerce, Harbin, China.
Nat Prod Res. 2021 Aug;35(15):2489-2497. doi: 10.1080/14786419.2019.1680668. Epub 2019 Nov 1.
Butyrolactone I, one of the major secondary metabolites of fungus , is a selective cdc2 kinase inhibitor. In the present study, the metabolism of butyrolactone I in male Wistar rats was investigated by characterising metabolites excreted into faeces. Following an oral dose of 40 mg/kg butyrolactone I, two phase I metabolites were isolated from the faeces of rat. The new structure was identified on the spectroscopic data analysis. The new compound and known compound were tested for their cytotoxicity, antimicrobial and antioxidant activity. and showed significant free radical scavenging ability. also showed strong inhibitory activity against .
丁内酯I是真菌的主要次生代谢产物之一，是一种选择性细胞周期蛋白依赖性激酶2（cdc2）抑制剂。在本研究中，通过对雄性Wistar大鼠粪便中排泄的代谢产物进行表征，研究了丁内酯I在大鼠体内的代谢情况。口服40mg/kg丁内酯I后，从大鼠粪便中分离出两种I相代谢产物。通过光谱数据分析确定了新的结构。对新化合物和已知化合物进行了细胞毒性、抗菌和抗氧化活性测试。[新化合物]和[已知化合物]表现出显著的自由基清除能力。[新化合物]对[某种菌]也表现出强烈的抑制活性。
