海洋真菌 C23-3 发酵大豆得到的一种抗炎异黄酮
An anti-inflammatory isoflavone from soybean inoculated with a marine fungus C23-3.
机构信息
College of Food Science and Technology, Guangdong Provincial Key Laboratory of Aquatic Product Processing and Safety, Guangdong Province Engineering Laboratory for Marine Biological Products, Research Institute for Marine Drugs and Nutrition, Guangdong Ocean University , Zhanjiang, China.
Marine Medicine Research and Development Center, Shenzhen Institute of Guangdong Ocean University , Shenzhen, China.
出版信息
Biosci Biotechnol Biochem. 2020 Aug;84(8):1546-1553. doi: 10.1080/09168451.2020.1764838. Epub 2020 May 20.
A new isoflavone derivative compound (psoralenone) was isolated from soybean inoculated with a marine fungus C23-3, together with seven known compounds including isoflavones -, butyrolactone I () and blumenol A (). Their structures were elucidated by MS, NMR, and ECD. Psoralenone displayed moderate anti-inflammatory activity in the LPS-induced RAW264.7 cell model. Compound (genistein) showed moderate acetylcholinesterase (AChE) inhibitory activity whereas compounds (biochanin A), (psoralenol), and exhibited potent larvicidal activity against brine shrimp. Compounds (daidzein), (4'-hydroxy-6,7-dimethoxyisoflavone), and - showed broad-spectrum anti-microbial activity, and compound also showed moderate 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging activity.
从大豆接种海洋真菌 C23-3 中分离到一种新的异黄酮衍生物化合物（补骨脂素酮），以及包括异黄酮、-丁内酯 I () 和白杨素 A () 在内的七种已知化合物。它们的结构通过 MS、NMR 和 ECD 阐明。补骨脂素酮在 LPS 诱导的 RAW264.7 细胞模型中表现出中等的抗炎活性。化合物 () 显示出中等的乙酰胆碱酯酶 (AChE) 抑制活性，而化合物 ()、() 和 () 对卤虫表现出很强的杀虫活性。化合物 ()、()、() 显示出广谱的抗菌活性，化合物 () 也显示出中等的 2,2-二苯基-1-苦基肼 (DPPH) 自由基清除活性。
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