Wagner M M, Campbell M J, Edwards R E
Clin Exp Immunol. 1979 Nov;38(2):323-31.
Peripheral blood leucocyte counts, and E binding rosettes were measured on 138 men on five separate occasions. Little effect was seen from age, or length of asbestos exposure. Overall the most marked effect was that obtained from smoking. Most relevant was an increase in percentage of E-rosettes read after 1 1/2 hrs, which was obtained in the group of those with radiological evidence of fibrosis who smoked. Restricted to subjects with small opacities, those who smoke have a significantly higher (P less than 0.05) percentage E 1 1/2 hr rosettes than those who do not smoke. (Percentage E rosettes read overnight remained unaltered by smoking or X-ray). This increase was found on each occasion that it was measured. Since the absolute number of T lymphocytes rosetting at 1 1/2 hr did not increase, it is suggested that there is either no stimulation of the central pool of T lymphocytes or a decrease in the absolute number of T lymphocytes which could only rosette overnight.
对138名男性在五个不同时间点进行了外周血白细胞计数和E花环检测。年龄和石棉接触时长的影响不大。总体而言，最显著的影响来自吸烟。最相关的是，在有纤维化放射学证据的吸烟组中，1.5小时后读取的E花环百分比有所增加。仅限于有小阴影的受试者，吸烟者1.5小时E花环的百分比显著高于不吸烟者（P<0.05）。（过夜读取的E花环百分比不受吸烟或X射线影响）。每次测量时都发现了这种增加。由于1.5小时时形成花环的T淋巴细胞绝对数量没有增加，因此表明要么T淋巴细胞中央池没有受到刺激，要么只能过夜形成花环的T淋巴细胞绝对数量减少。
