温石棉对体外单核细胞的影响。
Effects of chrysotile asbestos on mononuclear cells in vitro.
作者信息
Kagamimori S, Scott M P, Brown D G, Edwards R E, Wagner M M
出版信息
Br J Exp Pathol. 1980 Feb;61(1):55-60.
Chrysotile asbestos (400 micrograms/ml) was not found to be cytotoxic towards human blood lymphocytes in culture over a 72 h period, although there was indirect evidence of cytoxicity towards plastic adherent mononuclear cells (PAM). There was significant suppression of 3H-thymidine incorporation into cells cultured with phytohaemagglutinin (PHA) in the presence of fibres. It was found even when chrysotile was added 24 h after PHA. No suppression was found for chrysotile-treated PAM-depleted cultures in comparison to control cultures. Antibody-dependent cell-mediated cytotoxicty (ADCC) was inhibited by the presence of chrysotile, and appeared to be due to prevention of contact between antibody-coated target cells and effector cells.
温石棉（400微克/毫升）在72小时的培养期内未被发现对人血淋巴细胞具有细胞毒性，尽管有间接证据表明其对塑料贴壁单核细胞（PAM）具有细胞毒性。在有纤维存在的情况下，用植物血凝素（PHA）培养的细胞中，3H-胸腺嘧啶核苷掺入受到显著抑制。即使在PHA加入24小时后添加温石棉也能发现这种抑制作用。与对照培养物相比，温石棉处理的PAM耗尽培养物未发现抑制作用。温石棉的存在会抑制抗体依赖性细胞介导的细胞毒性（ADCC），这似乎是由于阻止了抗体包被的靶细胞与效应细胞之间的接触。
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