Gupta S, Malaviya A N, Rajagopalan P, Good R A
Clin Exp Immunol. 1979 Nov;38(2):342-7.
Peripheral blood lymphocytes from twenty patients with progressive systemic sclerosis (PSS) were analysed for the numbers and proportions of B lymphocytes possessing surface immunoglobulin, cells with Fc receptors, T cella and T cells with receptors for IgM (T mu) or IgG (T gamma). In patients with PSS, B cells and lymphocytes with Fc receptors were comparable in both numbers and proportions to those of the control group. Circulating T lymphocytes were significantly fewer in the patient group. T mu cells were decreased and T gamma cells increased, resulting in lower T mu/T gamma ratios as compared to controls. This study demonstrates a profound imbalance between T mu and T gamma cells (containing a population of helper or suppressor cells, respectively). These results are discussed in relation to immunodeficiencies observed in patients with PSS.
对20例进行性系统性硬化症（PSS）患者的外周血淋巴细胞进行分析，以检测具有表面免疫球蛋白的B淋巴细胞、具有Fc受体的细胞、T细胞以及具有IgM受体（Tμ）或IgG受体（Tγ）的T细胞的数量和比例。在PSS患者中，具有Fc受体的B细胞和淋巴细胞在数量和比例上与对照组相当。患者组中循环T淋巴细胞明显减少。Tμ细胞减少而Tγ细胞增加，导致与对照组相比Tμ/Tγ比值降低。本研究表明Tμ细胞和Tγ细胞（分别包含一群辅助细胞或抑制细胞）之间存在严重失衡。结合PSS患者中观察到的免疫缺陷对这些结果进行了讨论。
