Merrill J E, Biberfeld G, Landin S, Sidén A, Norrby E
Clin Exp Immunol. 1980 Nov;42(2):345-54.
Proportions of T cells and T cell subsets, as identified by their Fc receptors (FcR) for IgM and IgG (Tmu and T gamma), were determined in the peripheral blood lymphocyte (PBL) and cerebrospinal fluid (CSF) lymphocyte populations in patients with multiple sclerosis (MS). On average, MS patients had 79% total T cells (62% of which were T gamma, 66% Tmu) in CSF lymphocytes compared to 66% total T cells (30% T gamma, 63% Tmu) in PBL. Normal age- and sex-matched controls PBL had 74% total T cells (20% T gamma, 54% Tmu). By direct observation using an indirect immunofluorescence assay, 41% of the CSF T gamma cells in MS patients bore receptors for IgM; these cells were designated T gamma mu and, according to the double-marker analysis, did not seem to correlate with disease stage. In MS PBL, 20% of T gamma cells were T gamma mu compared to 9% in the control PBL T gamma population. Thus, MS patients had a higher proportion of total T cells, T gamma cells and T gamma mu cells in their CSF than in their peripheral blood and than those populations found in normal control blood. The significance of this T gamma mu population for the continuing disease state in MS is discussed.
通过针对IgM和IgG的Fc受体(FcR)鉴定的T细胞及T细胞亚群比例(Tmu和Tγ),在多发性硬化症(MS)患者的外周血淋巴细胞(PBL)和脑脊液(CSF)淋巴细胞群体中进行了测定。平均而言,MS患者CSF淋巴细胞中总T细胞占79%(其中Tγ占62%,Tmu占66%),而PBL中总T细胞占66%(Tγ占30%,Tmu占63%)。年龄和性别匹配的正常对照PBL中总T细胞占74%(Tγ占20%,Tmu占54%)。通过间接免疫荧光测定法直接观察发现,MS患者CSF中的Tγ细胞有41%带有IgM受体;这些细胞被指定为Tγμ,根据双标记分析,它们似乎与疾病阶段无关。在MS患者的PBL中,20%的Tγ细胞为Tγμ,而对照PBL的Tγ细胞群体中这一比例为9%。因此,MS患者CSF中总T细胞、Tγ细胞和Tγμ细胞的比例高于外周血,也高于正常对照血液中的相应细胞群体。本文讨论了Tγμ细胞群体对MS持续疾病状态的意义。