T细胞亚群的原发性和继发性异常。
Primary and secondary abnormalities of T cell subpopulations.
作者信息
Trompeter R S, Layward L, Hayward A R
出版信息
Clin Exp Immunol. 1978 Dec;34(3):388-92.
Abstract
Ataxia telangiectasia patients had normal numbers of T lymphocytes in their blood but IgM-binding T lymphocytes (T) were selectively reduced. These changes provide a cellular basis for the defects in cell-mediated immunity which occur in this primary condition. One child with severe combined immunodeficiency lacked both T and IgG-binding (T) T lymphocytes, but no consistent abnormalities of T cell subsets were found in other primary immunodeficiency syndromes. Secondary increases in IgG-binding T lymphocytes (T) were found in children receiving steroids.
摘要
共济失调毛细血管扩张症患者血液中的T淋巴细胞数量正常，但IgM结合性T淋巴细胞（T）选择性减少。这些变化为这种原发性疾病中发生的细胞介导免疫缺陷提供了细胞基础。一名患有严重联合免疫缺陷的儿童既缺乏T淋巴细胞，也缺乏IgG结合性T淋巴细胞（T），但在其他原发性免疫缺陷综合征中未发现T细胞亚群的一致异常。接受类固醇治疗的儿童中发现IgG结合性T淋巴细胞（T）继发性增加。
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本文引用的文献
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Role of suppressor T cells in pathogenesis of common variable hypogammaglobulinaemia.抑制性T细胞在常见变异型低丙种球蛋白血症发病机制中的作用。
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