Fu Jiaxin, Li Bai, Mei Huihui, Chang Yongxin, Xu Kuoxi
College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, Henan, China.
College of Chemistry and Chemical Engineering, Henan University, Kaifeng, 475004, Henan, China.
Spectrochim Acta A Mol Biomol Spectrosc. 2020 Feb 15;227:117678. doi: 10.1016/j.saa.2019.117678. Epub 2019 Oct 22.
Two novel Schiff-base fluorescent probers SQ and NQ based on 8-hydroxyquinoline moiety were designed and synthesized. The both probes were capable of binding with Al by naked eye detection to produce a significant fluorescence enhancement response with a detection limit of 1.48 × 10 and 4.23 × 10 M, respectively. At the same time, the formed complexes SQ-Al and NQ-Al could sequentially detect F, and the detection limits of F were determined to be 1.64 × 10 and 3.58 × 10 M, respectively. The "off-on-off" fluorescence response process demonstrated that the binding were reversible. The probes were further successfully utilized to detect Al and F in vitro PC12 cells.
设计并合成了两种基于8-羟基喹啉部分的新型席夫碱荧光探针SQ和NQ。两种探针都能够通过肉眼检测与铝结合，分别产生显著的荧光增强响应，检测限分别为1.48×10和4.23×10⁻⁶ M。同时，形成的配合物SQ-Al和NQ-Al可以依次检测氟离子，氟离子的检测限分别确定为1.64×10⁻⁶和3.58×10⁻⁶ M。“关-开-关”荧光响应过程表明这种结合是可逆的。这些探针进一步成功地用于体外PC12细胞中铝和氟的检测。
