基于喹啉席夫碱的高选择性和高灵敏度铝(III)荧光探针及其细胞成像研究。
A highly selective and sensitive turn-on probe for aluminum(III) based on quinoline Schiff's base and its cell imaging.
机构信息
College of Chemistry and Chemical Engineering, University of South China, 28 Changsheng West Road Hengyang, Hunan 421001, PR China.
College of Chemistry and Chemical Engineering, University of South China, 28 Changsheng West Road Hengyang, Hunan 421001, PR China.
出版信息
Spectrochim Acta A Mol Biomol Spectrosc. 2018 Feb 5;190:104-110. doi: 10.1016/j.saa.2017.09.007. Epub 2017 Sep 8.
A reversible Schiff's base fluorescence probe for Al, (3,5-dichloro-2- hydroxybenzylidene) quinoline-2-carbohydrazide (QC), based on quinoline derivative has been designed, synthesized and evaluated. The QC exhibited a high sensitivity and selectivity toward Al in EtOH-HO (v/v=1:9, pH=6) by forming a 1:1 complex with Al and the detection limit of QC for Al was as low as 0.012μM. Furthermore, these results displayed that the binding of QCAl was broken by F, so this system could be used to monitor F in the future. The enhancement fluorescence of the QC could be attributed to the inhibition of PET and ESIPT and the emergency of CHEF process induced by Al. More importantly, QC was not only successfully used for the determination of trace Al in the tap water and the human blood serum, but was valid for fluorescence imaging of Al in the Hela cells.
一种基于喹啉衍生物的、可将 Al 还原为席夫碱荧光探针，(3,5-二氯-2-羟基苯亚甲基)喹啉-2-甲酰肼(QC)，已经被设计、合成并进行了评估。QC 在 EtOH-HO(v/v=1:9, pH=6)中对 Al 具有高灵敏度和选择性，通过与 Al 形成 1:1 的配合物，检测限低至 0.012μM。此外，这些结果表明，QCAl 的结合可以被 F 打破，因此该系统未来可用于监测 F。QC 的增强荧光可以归因于抑制 PET 和 ESIPT 以及 Al 诱导的 CHEF 过程的出现。更重要的是，QC 不仅成功地用于测定自来水中和人血清中的痕量 Al，而且还可用于 HeLa 细胞中 Al 的荧光成像。
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