Kvåle G, Heuch I
Department of Hygiene and Social Medicine, University of Bergen, Norway.
Cancer. 1988 Oct 15;62(8):1625-31. doi: 10.1002/1097-0142(19881015)62:8<1625::aid-cncr2820620828>3.0.co;2-k.
Relationships between menstrual factors and breast cancer risk were investigated in a prospective study of 63,090 Norwegian women. A total of 1565 cases of breast cancer occurred during follow-up from 1961 through 1980. The risk of breast cancer decreased with increasing age at menarche (P = 0.06) and increased with increasing age at menopause (P = 0.005) in analyses adjusted for age, urban/rural place of residence, parity, and age at first and last birth. The results correspond to an average increase in breast cancer risk of 4.0% for each year of decrease in age at menarche, and an increase in risk of 3.6% for each year of increase in age at menopause. The protective effect of early menopause was strongest for breast cancer diagnosed in patients 80 years of age or older. No clear relationship was seen between menstrual irregularities and breast cancer risk.
在一项对63090名挪威女性的前瞻性研究中，研究了月经因素与乳腺癌风险之间的关系。在1961年至1980年的随访期间，共发生了1565例乳腺癌病例。在根据年龄、城乡居住地、产次以及首次和末次生育年龄进行调整的分析中，乳腺癌风险随着初潮年龄的增加而降低（P = 0.06），并随着绝经年龄的增加而增加（P = 0.005）。结果表明，初潮年龄每降低一岁，乳腺癌风险平均增加4.0%，绝经年龄每增加一岁，风险增加3.6%。早期绝经对80岁及以上患者诊断出的乳腺癌的保护作用最强。月经不规律与乳腺癌风险之间未发现明确关系。
