Department of Public Health, University of Copenhagen, Øster Farimagsgade 5, P.O. Box 2099, 1014, Copenhagen K, Denmark.
Center for Healthy Aging, University of Copenhagen, Blegdamsvej 3B, 2200, Copenhagen N, Denmark.
Qual Life Res. 2020 Apr;29(4):1047-1054. doi: 10.1007/s11136-019-02348-w. Epub 2019 Nov 2.
Low birth weight has been associated with a higher risk of reduced quality of life (QoL) in children, adolescents, and young adults, but the influence seems to diminish over time. However, previous studies have mainly focused on health-related QoL and compared individuals with low birth weight with individuals without low birth weight. The purpose of the present cohort study was to investigate the influence of the entire range of birth weights on three distinct measures of QoL in midlife.
The study population consisted of all live-born singletons from the Copenhagen Perinatal Cohort (CPC, 1959-1961) who participated in a 50-year follow-up examination in 2009-2011 (N = 2079). Birth weight was measured by three pediatricians at birth. QoL was measured at the follow-up by the participants' scores on three QoL self-report measures: The Satisfaction With Life Scale, the Vitality Scale of the Medical Outcomes Study 36-Item Short-Form Health Survey, and a single-item QoL measure based on the question: "How is your quality of life at the moment?". General linear regression and binary logistic regression were used to estimate the association between birth weight and QoL in midlife.
Small, curvilinear associations of birth weight with life satisfaction, vitality, and the single-item QoL measure were found, suggesting that both low and high birth weights increase the risk of low satisfaction with life, low vitality and low QoL.
The study findings suggest that low and high-range birth weight exert a lasting influence on distinct, but complementary aspects of QoL in midlife.
低出生体重与儿童、青少年和年轻成年人生活质量（QoL）降低的风险增加有关，但这种影响似乎随着时间的推移而减弱。然而，以前的研究主要集中在与健康相关的 QoL 上，比较了低出生体重的个体和没有低出生体重的个体。本队列研究的目的是调查整个出生体重范围对中年人三种不同 QoL 测量的影响。
研究人群包括来自哥本哈根围产期队列（CPC，1959-1961 年）的所有活产单胎，并参加了 2009-2011 年的 50 年随访检查（N=2079）。出生体重由三位儿科医生在出生时测量。QoL 在随访时通过参与者在三个 QoL 自我报告测量中的得分来衡量：生活满意度量表、医疗结果研究 36 项短格式健康调查活力量表和基于问题的单一项目 QoL 测量：“此刻您的生活质量如何？”。使用一般线性回归和二元逻辑回归来估计出生体重与中年人 QoL 之间的关联。
发现出生体重与生活满意度、活力和单一项目 QoL 测量之间存在小的曲线关联，表明低出生体重和高出生体重都会增加生活满意度低、活力低和 QoL 低的风险。
研究结果表明，低出生体重和高出生体重对中年人 QoL 的不同但互补方面产生持久影响。
