Stice Eric, Yokum Sonja, Voelker Pascale
Stanford University, Stanford, CA 94305, USA.
Oregon Research Institute, Eugene, OR, 97403, USA.
Soc Cogn Affect Neurosci. 2020 Nov 10;15(10):1135-1144. doi: 10.1093/scan/nsz081.
Although the fat mass and obesity-associated gene (FTO) correlates with elevated body mass, it is unclear how it contributes to overeating. We tested if individuals with the A allele show greater reward region responsivity to receipt and anticipated receipt of food and money and palatable food images. We also tested if these individuals show greater future weight gain. Initially healthy weight adolescents (Study 1, N = 162; Study 2, N = 135) completed different functional magnetic resonance imaging paradigms and had their body mass measured annually over 3 years. Adolescents with the AA or AT genotypes showed less precuneus and superior parietal lobe response and greater cuneus and prefrontal cortex response to milkshake receipt and less putamen response to anticipated milkshake receipt than those with the TT genotype in separate analyses of each sample. Groups did not differ in response to palatable food images, and receipt and anticipated receipt of money, or in weight gain over 3-year follow-up. Results suggest that initially healthy weight adolescents with vs without the FTO A allele show differential responsivity to receipt and anticipated receipt of food but do not differ in neural response to palatable food images and monetary reward and do not show greater future weight gain.
尽管脂肪量与肥胖相关基因（FTO）与体重增加有关，但其如何导致暴饮暴食尚不清楚。我们测试了携带A等位基因的个体在接受和预期接受食物、金钱以及美味食物图片时，奖励区域的反应是否更强烈。我们还测试了这些个体未来体重增加是否更多。最初体重健康的青少年（研究1，N = 162；研究2，N = 135）完成了不同的功能磁共振成像范式，并在3年中每年测量他们的体重。在对每个样本的单独分析中，与携带TT基因型的青少年相比，携带AA或AT基因型的青少年在接受奶昔时楔前叶和顶上叶的反应较弱，楔叶和前额叶皮质的反应较强，而在预期接受奶昔时壳核的反应较弱。各组在对美味食物图片的反应、接受和预期接受金钱方面，以及在3年随访中的体重增加方面没有差异。结果表明，最初体重健康的青少年中，携带与未携带FTO A等位基因者在接受和预期接受食物时的反应存在差异，但在对美味食物图片和金钱奖励的神经反应方面没有差异，且未来体重增加也没有更多。
