Touger M, Gallagher E J, Tyrell J
Department of Medicine, Bronx Municipal Hospital, Albert Einstein College of Medicine.
Ann Emerg Med. 1995 Apr;25(4):481-3. doi: 10.1016/s0196-0644(95)70262-8.
To test the hypothesis that venous carboxyhemoglobin (V-COHb) levels accurately predict arterial (A-COHb) levels.
Prospective comparison of A-COHb and V-COHb levels in patients with suspected carbon monoxide (CO) poisoning.
Municipal hospital emergency department with contiguous multiplace hyperbaric chamber staffed 24 hours a day.
Unselected convenience sample of 61 adults with suspected CO toxicity.
Simultaneous sampling of arterial and venous blood.
Correlation between V-COHb and A-COHb showed an r value of .99 (95%CI, .99 to .99), and an r2 value of .98. Agreement between V-COHb and A-COHb levels was examined by use of a plot of arteriovenous differences against the mean of the two measurements. The mean arteriovenous difference was .15% COHb (95%CI, .13% to .45%), with 95% of the differences ranging from 2.4% COHb to -2.1% COHb.
Venous COHb levels predict arterial levels with a high degree of accuracy. Patients with suspected CO poisoning can be screened with the use of venous blood, without the need for arterial puncture.
检验静脉血碳氧血红蛋白（V-COHb）水平能否准确预测动脉血碳氧血红蛋白（A-COHb）水平这一假设。
对疑似一氧化碳（CO）中毒患者的A-COHb和V-COHb水平进行前瞻性比较。
市立医院急诊科，其附近设有24小时值班的多处高压氧舱。
61名疑似CO中毒的成年患者的非选择性便利样本。
同时采集动脉血和静脉血。
V-COHb与A-COHb之间的相关性显示r值为0.99（95%CI，0.99至0.99），r²值为0.98。通过绘制动静脉差值与两次测量均值的关系图，检验了V-COHb和A-COHb水平之间的一致性。平均动静脉差值为0.15% COHb（95%CI，0.13%至0.45%），95%的差值范围为-2.4% COHb至2.1% COHb。
静脉血COHb水平能高度准确地预测动脉血水平。疑似CO中毒的患者可以通过检测静脉血进行筛查，无需进行动脉穿刺。
