• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

抗逆转录病毒治疗期间的持续性HIV-1病毒血症：测量与机制

Persistent HIV-1 Viremia on Antiretroviral Therapy: Measurement and Mechanisms.

作者信息

Jacobs Jana L, Halvas Elias K, Tosiano Melissa A, Mellors John W

机构信息

Division of Infectious Diseases, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, United States.

出版信息

Front Microbiol. 2019 Oct 15;10:2383. doi: 10.3389/fmicb.2019.02383. eCollection 2019.

DOI:10.3389/fmicb.2019.02383
PMID:31681237
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6804636/
Abstract

HIV-1 viremia persists at low-levels despite clinically effective antiretroviral therapy (ART). Here we review new methods to quantify and characterize persistent viremia at the single genome level, and discuss the mechanisms of persistence including clonal expansion of infected cells and tissue origins of viremia. A deeper understanding of how viremia persists on ART is critically important to the design of therapies to eliminate viremia and achieve a functional cure for HIV-1.

摘要

尽管抗逆转录病毒疗法（ART）在临床上有效，但HIV-1病毒血症仍以低水平持续存在。在此，我们综述了在单基因组水平上定量和表征持续性病毒血症的新方法，并讨论了持续性的机制，包括受感染细胞的克隆扩增和病毒血症的组织来源。深入了解病毒血症在ART治疗下如何持续存在，对于设计消除病毒血症并实现HIV-1功能性治愈的疗法至关重要。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/648e/6804636/d8f43db1d354/fmicb-10-02383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/648e/6804636/d8f43db1d354/fmicb-10-02383-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/648e/6804636/d8f43db1d354/fmicb-10-02383-g001.jpg

相似文献

1
Persistent HIV-1 Viremia on Antiretroviral Therapy: Measurement and Mechanisms.抗逆转录病毒治疗期间的持续性HIV-1病毒血症：测量与机制
Front Microbiol. 2019 Oct 15;10:2383. doi: 10.3389/fmicb.2019.02383. eCollection 2019.
2
ART suppresses plasma HIV-1 RNA to a stable set point predicted by pretherapy viremia.抗逆转录病毒疗法将血浆中的HIV-1 RNA抑制到由治疗前病毒血症预测的稳定水平。
PLoS Pathog. 2007 Apr;3(4):e46. doi: 10.1371/journal.ppat.0030046.
3
Single-molecule techniques to quantify and genetically characterise persistent HIV.单分子技术定量和遗传表征持续性 HIV。
Retrovirology. 2018 Jan 9;15(1):3. doi: 10.1186/s12977-017-0386-x.
4
Advances in detection and monitoring of plasma viremia in HIV-infected individuals receiving antiretroviral therapy.抗逆转录病毒治疗的 HIV 感染者血浆病毒血症的检测和监测进展。
Curr Opin HIV AIDS. 2013 Mar;8(2):87-92. doi: 10.1097/COH.0b013e32835d80af.
5
HIV reservoirs: pathogenesis and obstacles to viral eradication and cure.HIV 储库：发病机制以及病毒清除和治愈的障碍。
AIDS. 2012 Jun 19;26(10):1261-8. doi: 10.1097/QAD.0b013e328353f3f1.
6
Measurement of plasma HIV-1 RNA below the limit of quantification (<20 copies/mL) of commercial assays with the integrase HIV RNA single-copy assay.采用整合酶 HIV RNA 单拷贝检测法对商业检测法无法定量 (<20 拷贝/mL) 的血浆 HIV-1 RNA 进行测量。
J Clin Virol. 2018 Nov;108:50-52. doi: 10.1016/j.jcv.2018.09.003. Epub 2018 Sep 10.
7
Evidence for persistent low-level viremia in individuals who control human immunodeficiency virus in the absence of antiretroviral therapy.在未接受抗逆转录病毒治疗的情况下控制人类免疫缺陷病毒的个体中存在持续性低水平病毒血症的证据。
J Virol. 2009 Jan;83(1):329-35. doi: 10.1128/JVI.01763-08. Epub 2008 Oct 22.
8
Levels of HIV-1 persistence on antiretroviral therapy are not associated with markers of inflammation or activation.接受抗逆转录病毒治疗的患者体内HIV-1持续存在水平与炎症或激活标志物无关。
PLoS Pathog. 2017 Apr 20;13(4):e1006285. doi: 10.1371/journal.ppat.1006285. eCollection 2017 Apr.
9
Continued production of drug-sensitive human immunodeficiency virus type 1 in children on combination antiretroviral therapy who have undetectable viral loads.接受联合抗逆转录病毒治疗且病毒载量检测不到的儿童中持续产生1型药物敏感型人类免疫缺陷病毒。
J Virol. 2004 Jan;78(2):968-79. doi: 10.1128/jvi.78.2.968-979.2004.
10
Rate of and predicting factors for virologic failure in HIV-infected patients with persistent low-level viremia under antiretroviral therapy.接受抗逆转录病毒治疗的持续性低水平病毒血症HIV感染患者的病毒学失败率及预测因素
J Int Assoc Provid AIDS Care. 2015 Jan-Feb;14(1):12-6. doi: 10.1177/2325957414527168. Epub 2014 Mar 20.

引用本文的文献

1
Proviruses in CD4 T cells reactive to autologous antigens contribute to nonsuppressible HIV-1 viremia.对自身抗原产生反应的CD4 T细胞中的前病毒会导致无法抑制的HIV-1病毒血症。
Sci Transl Med. 2025 Aug 13;17(811):eadu4643. doi: 10.1126/scitranslmed.adu4643.
2
HIV-1 testing in the context of expanding PrEP modalities.在扩大暴露前预防（PrEP）模式背景下的HIV-1检测
J Int AIDS Soc. 2025 Jul;28 Suppl 2(Suppl 2):e26491. doi: 10.1002/jia2.26491.
3
A Guide to the Evolving Clinical Landscape of Low-Level Viremia Among Persons with HIV in the Modern Treatment Era.

本文引用的文献

1
HIV Rebound Is Predominantly Fueled by Genetically Identical Viral Expansions from Diverse Reservoirs.HIV 反弹主要是由来自不同储存库的遗传上相同的病毒扩增所驱动的。
Cell Host Microbe. 2019 Sep 11;26(3):347-358.e7. doi: 10.1016/j.chom.2019.08.003. Epub 2019 Aug 27.
2
Persistent HIV-infected cells in cerebrospinal fluid are associated with poorer neurocognitive performance.脑脊液中持续存在的 HIV 感染细胞与较差的神经认知表现相关。
J Clin Invest. 2019 Jul 15;129(8):3339-3346. doi: 10.1172/JCI127413.
3
Impact of Myeloid Reservoirs in HIV Cure Trials.
现代治疗时代HIV感染者低水平病毒血症不断演变的临床状况指南
Curr HIV/AIDS Rep. 2025 Jun 26;22(1):39. doi: 10.1007/s11904-025-00743-2.
4
The heart of the matter: modeling HIV-associated cardiovascular comorbidities in nonhuman primate models.问题的核心：在非人类灵长类动物模型中模拟与HIV相关的心血管合并症
Front Cell Infect Microbiol. 2025 Apr 22;15:1556315. doi: 10.3389/fcimb.2025.1556315. eCollection 2025.
5
Expression of HIV from a 1-LTR circular DNA in the absence of integration.在缺乏整合的情况下，HIV从1-长末端重复序列环状DNA中的表达。
Retrovirology. 2025 Mar 17;22(1):2. doi: 10.1186/s12977-025-00658-1.
6
Impact of Switching to Long-Acting Injectable Cabotegravir Plus Rilpivirine on Rectal HIV-1 RNA Shedding and Implications for Transmission Risk.换用长效注射用卡博特韦加rilpivirine对直肠HIV-1 RNA脱落的影响及其对传播风险的意义。
J Infect Dis. 2025 Apr 15;231(4):e792-e802. doi: 10.1093/infdis/jiaf117.
7
HIV-1 Low-Level Viremia Predicts Viral Failure in Participants on Antiretroviral Therapy in the Swiss HIV Cohort Study.在瑞士HIV队列研究中，HIV-1低水平病毒血症可预测接受抗逆转录病毒治疗参与者的病毒学失败。
Clin Infect Dis. 2025 Aug 1;81(1):57-66. doi: 10.1093/cid/ciae569.
8
Management of low-level HIV viremia during antiretroviral therapy: Delphi consensus statement and appraisal of the evidence.抗逆转录病毒治疗期间低水平 HIV 病毒血症的管理：德尔菲共识声明和证据评估。
Sex Transm Infect. 2024 Oct 17;100(7):442-449. doi: 10.1136/sextrans-2024-056199.
9
B/F/TAF forgiveness to non-adherence.B/F/TAF 对不依从的宽恕。
Sex Transm Infect. 2024 Oct 17;100(7):418-422. doi: 10.1136/sextrans-2024-056202.
10
Low-Level Viremia among Adults Living with HIV on Dolutegravir-Based First-Line Antiretroviral Therapy Is a Predictor of Virological Failure in Botswana.在博茨瓦纳，接受多替拉韦利匹韦林为基础的一线抗逆转录病毒治疗的艾滋病毒感染者中低水平病毒血症是病毒学失败的预测指标。
Viruses. 2024 May 1;16(5):720. doi: 10.3390/v16050720.
HIV 治愈试验中髓系储库的影响。
Curr HIV/AIDS Rep. 2019 Apr;16(2):129-140. doi: 10.1007/s11904-019-00438-5.
4
HIV-1 reservoirs in urethral macrophages of patients under suppressive antiretroviral therapy.在接受抑制性抗逆转录病毒治疗的患者的尿道巨噬细胞中存在 HIV-1 储库。
Nat Microbiol. 2019 Apr;4(4):633-644. doi: 10.1038/s41564-018-0335-z. Epub 2019 Feb 4.
5
A quantitative approach for measuring the reservoir of latent HIV-1 proviruses.一种定量方法用于测量潜伏 HIV-1 前病毒库。
Nature. 2019 Feb;566(7742):120-125. doi: 10.1038/s41586-019-0898-8. Epub 2019 Jan 30.
6
A Simpler and More Sensitive Single-Copy HIV-1 RNA Assay for Quantification of Persistent HIV-1 Viremia in Individuals on Suppressive Antiretroviral Therapy.一种更简单、更灵敏的单拷贝 HIV-1 RNA 检测方法，用于定量评估接受抑制性抗逆转录病毒治疗个体中持续性 HIV-1 病毒血症。
J Clin Microbiol. 2019 Feb 27;57(3). doi: 10.1128/JCM.01714-18. Print 2019 Mar.
7
Hematopoietic Stem and Progenitor Cells Are a Distinct HIV Reservoir that Contributes to Persistent Viremia in Suppressed Patients.造血干细胞和祖细胞是一个独特的 HIV 储库，导致抑制患者持续病毒血症。
Cell Rep. 2018 Dec 26;25(13):3759-3773.e9. doi: 10.1016/j.celrep.2018.11.104.
8
Characterization of the HIV-1 transcription profile after romidepsin administration in ART-suppressed individuals.在接受 ART 抑制的个体中，罗米地辛给药后 HIV-1 转录谱的特征。
AIDS. 2019 Mar 1;33(3):425-431. doi: 10.1097/QAD.0000000000002083.
9
Randomized Clinical Trial to Assess the Impact of the Broadly Neutralizing HIV-1 Monoclonal Antibody VRC01 on HIV-1 Persistence in Individuals on Effective ART.评估广泛中和性HIV-1单克隆抗体VRC01对接受有效抗逆转录病毒治疗的个体中HIV-1持续性影响的随机临床试验。
Open Forum Infect Dis. 2018 Oct 20;5(10):ofy242. doi: 10.1093/ofid/ofy242. eCollection 2018 Oct.
10
Ongoing HIV Replication During ART Reconsidered.抗逆转录病毒治疗期间持续的HIV复制再探讨。
Open Forum Infect Dis. 2017 Sep 19;4(3):ofx173. doi: 10.1093/ofid/ofx173. eCollection 2017 Summer.